Pioneering Medicines Principal Scientist/Associate Director

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship’s scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

About Flagship Pioneering:

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.     

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.   

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

 Position Summary:

We are seeking an innovative, independent and dynamic lab-based research scientist with broad expertise in molecular and cellular biology to join discovery biology team focused on developing innovative therapeutic drugs in the areas of cardiovascular, renal and pulmonary diseases. This individual will collaborate with in vivo biology, translational science and nonclinical groups to help execute on company strategy.

Key Responsibilities:

• Contribute to the drug discovery process with a goal to  nominate targets with proof of concepts studies
• Act as a leader of a team tasked with screening, characterization, and mechanism of action studies to elucidate signaling pathways for target identification, and validation utilizing  complex cellular models, various modalities, including small molecules, biologics, gene editing , and omics approaches through AI and ML
• Conduct research in areas of cardiovascular, pulmonary and/or renal disease space by acting as a subject matter expertise.
• Lead early drug projects in the cardiovascular, pulmonary and/or renal disease space, propose and champion new targets and novel approaches for disease treatment. 
• Design and execute in vitro and in vivo research plans to evaluate targets modulating pathways in cardiovascular, pulmonary and/or renal diseases
• Develop assays and implement new technologies to enable the delivery of high quality data-driven package and enable project decisions go/no-go portfolio transitions.
• Record and interpret experimental data, and present results to project team members.
• Collaborate with other scientists in a global matrixed dynamic environment fostering innovation and advance project activities. Develop and maintain external relationships/contacts.
•  Deliver impact to projects by identifying technical trends, both internal and external to your subject area.

Basic Requirements:

• PhD in relevant scientific discipline with 12+ years of relevant experience 
•  In-depth knowledge of (patho-)physiology of cardiovascular, renal and pulmonary mechanisms, including direct experience complex in vitro cell-based platforms recapitulating human disease phenotype and in vivo models of disease progression
•  Extensive “hands-on” experience and track-record in the use of a wide range of cellular, biochemical and functional assays and technologies to unravel complex cellular signaling pathways.
• Track record of leading discovery projects to elucidate mechanistic target biology and validation in the disease areas.
• A proven scientific impact on innovation through a solid publication track record and strong external scientific network with academic experts.
  * Excellent oral and written English communication skills, with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally

Additional Qualifications:

• Industrial experience or experience working with academic/industrial collaborators and/or CROs preferred
• Research background in immunology, or metabolism.
• Hands-on experience with genetic-based approaches such as CRISPR and RNA interference is a plus

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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