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Vertex Pharmaceuticals

Develops therapies for serious genetic diseases

Senior Principal AI Engineer

Applied Machine LearningConfirmed live in the last 24 hours
Full-timeBoston, MA, USARemote

About the Job

Requirements

  • An advanced degree in Computer Science, Engineering, Artificial Intelligence, Machine Learning, or a related technical field, or an equivalent combination of education and experience.
  • At least 10 years of experience designing and building enterprise-grade AI/ML platforms and distributed systems.
  • Deep expertise in agentic AI architectures, large language model-based applications, and platform engineering.
  • Proven experience with retrieval-augmented generation systems, vector search, document retrieval, and knowledge integration patterns.
  • Strong experience with AI orchestration frameworks, workflow engines, and multi-step agent execution patterns.
  • Demonstrated experience designing centralized operational platforms for monitoring, governance, observability, and control.
  • Experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.
  • Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for responsible use of AI coding assistants and software engineering agents across engineering teams.
  • Experience defining architecture, standards, and reusable services for large-scale enterprise environments.
  • Strong understanding of AI system evaluation, quality measurement, and performance optimization.
  • Experience partnering with cross-functional stakeholders and influencing technical direction across teams.
  • Ability to balance strategic architecture leadership with hands-on technical execution.
  • Agentic AI platform architecture, large language models, retrieval-augmented generation, AI orchestration and workflow design, agent monitoring and observability, AI governance, policies and controls, AI FinOps, AI Gateway/Control Tower architecture, evaluation frameworks for AI systems, platform engineering and reusable service design, distributed systems architecture, API and service design, knowledge retrieval systems, telemetry, logging, operational analytics, scalability, reliability, performance engineering, and security and enterprise controls for AI platforms.

Responsibilities

  • Define the technical vision, architecture, and roadmap for Vertex’s enterprise agentic AI platform.
  • Design and build reusable platform services that accelerate development of safe, reliable, and scalable AI-powered applications.
  • Lead architecture and implementation for retrieval-augmented generation pipelines, knowledge retrieval systems, prompt workflows, tool use, and agent orchestration.
  • Establish core frameworks for agent lifecycle management, including deployment, monitoring, observability, evaluation, and continuous improvement.
  • Develop scalable infrastructure patterns for enterprise AI workloads, including model integration, data access, and orchestration services.
  • Partner with product, engineering, data, security, and user experience teams to deliver common AI platform capabilities supporting multiple use cases across Vertex.
  • Establish best practices for AI reliability, evaluation, safety, and performance measurement.
  • Drive technical standards for platform APIs, service contracts, architecture patterns, and reusable components.
  • Evaluate emerging technologies, frameworks, and vendors in the AI and agentic ecosystem and make strategic recommendations.
  • Mentor engineers and influence cross-functional technical teams through architectural leadership and hands-on guidance.
  • Ensure platform solutions align with enterprise requirements for scalability, resilience, security, and maintainability.
  • Identify opportunities to expand platform capabilities and increase enterprise adoption as part of Vertex’s long-term AI strategy.
  • Build the shared architecture, services, and reusable capabilities that make it faster and safer to build AI-powered applications across Vertex.
  • Stand up and operate the centralized AI control plane for agent monitoring, observability, telemetry, policy enforcement, guardrails, usage analytics, and auditability.
  • Own the strategy, architecture, implementation, and day-to-day operation of the centralized AI Gateway/Control Tower as the enterprise control point for model access, routing, governance, cost management, and operational oversight.
  • Implement intelligent model routing, provider abstraction, fallback, failover, rate limiting, and workload optimization across approved models.
  • Manage AI FinOps, including token and consumption visibility, budgeting, chargeback/showback, cost allocation, forecasting, and model-cost optimization.
  • Implement centralized guardrails for content safety, prompt-injection defense, data-loss prevention, sensitive-data handling, and responsible AI policy enforcement.
  • Establish identity, access, security, privacy, regulatory compliance, and lifecycle governance controls for models, agents, tools, and AI interactions.
  • Manage end-to-end observability, telemetry, quality monitoring, latency and reliability metrics, incident response, and operational health.
  • Provide usage analytics, immutable audit trails, policy evidence, risk reporting, and executive-level transparency across the enterprise AI estate.
  • Manage model onboarding, approval, versioning, deprecation, resiliency, capacity, and third-party provider governance.
  • Build retrieval and knowledge systems, including RAG pipelines, vector search, document retrieval, and grounding patterns that make enterprise content usable by agents.
  • Manage agent deployment, versioning, evaluation frameworks, reliability measurement, and continuous improvement in production.
  • Establish platform APIs, service contracts, architecture patterns, and engineering practices for other teams to build against.

Desired Qualifications

  • Experience building enterprise AI platforms in regulated or highly governed environments.
  • Familiarity with human-in-the-loop workflows and responsible AI practices.
  • Experience implementing policy engines, guardrails, and audit frameworks for AI applications.
  • Knowledge of machine learning infrastructure, model serving, and production AI operations.
  • Experience with cloud-native architectures and modern DevOps/MLOps practices.
  • Exposure to user experience considerations for AI-powered applications and intelligent systems.
  • Ability to translate complex technical capabilities into scalable enterprise adoption strategies.
  • Experience leading technical teams through platform transformation initiatives.

About the Company

Vertex Pharmaceuticals

Develops therapies for serious genetic diseases

Vertex Pharmaceuticals develops medicines for serious diseases, with a focus on cystic fibrosis. It conducts extensive research and partners with other biotech firms to discover and develop new therapies, including ex vivo engineered cell treatments. Its products, such as ivacaftor, treat cystic fibrosis and other therapies undergo clinical testing to expand the pipeline. Revenue comes from selling approved drugs and from licensing and collaboration agreements. The company distinguishes itself through deep R&D investment, strategic partnerships, and a global reach aimed at addressing unmet medical needs. The overall goal is to bring effective new drugs to patients worldwide and improve outcomes and quality of life.

Company size
5,001-10,000
Company stage
IPO
Headquarters
Boston, MA
Founded
1989

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