Applications Scientist - Antibody Characterisation

Role Overview - Primary Objective

To help develop the capabilities of mass photometry (MP) for antibody characterisation in bioprocessing.

How you'll achieve it

Working in the Biology team alongside multidisciplinary engineers, chemists, and biologists, the Applications Scientist, Antibody Characterisation is responsible for designing, testing, and establishing new and optimised assays and workflows for mass photometry, with a focus on robust and reliable antibody measurements across existing and new modalities.  

The Applications Scientist, Antibody Characterisation will work cross-functionally to translate product requirements into technical solutions and help deliver next generation products, assays and workflows to support the utilisation and diversification of our instruments and consumable products, within existing and new application areas.

Key responsibilities for this role include:  

• Designing, implementing, and optimizing protocols, assays, and workflows for mass photometry, with a particular focus on antibody measurements.
• Routine testing of new surfaces, cassettes, calibrants, and reagents, to aid product development.
• Provide technical and scientific insight into the development and delivery of new technologies, assays, workflows, and protocols.
• Identify and source appropriate biomolecular targets across existing and new modalities, to facilitate product development.
• Analyse complex data sets to evaluate mass photometry performance, in comparison to alternative methods.
• Work closely with applications specialists, systems engineers, software developers and external partners to deliver new designs or features and application-specific solutions.
• Preparing technical reports, protocols, SOPs, application notes, and user guides to support product adoption and compliance.
• Actively participate in the growth of Refeyn’s IP portfolio and identify patentable IP.
• Keep up to date on the cutting-edge advances in the fields of light microscopy, light scattering and single molecule bio-analytics, as well as new modalities within the field of antibodies.
• Identify new application targets and novel approaches to support our technology roadmap.

We are ideally looking for someone with the following skills and experience:

• MSc or PhD in Biolgy, Biochemistry, Biotechnology, or a related field.
• Background in protein biochemistry, particularly working with antibodies and characterisation (with knowledge of purification).  
• Practical experience designing experiments, developing assays and workflows, and optimising performance of bioanalytical instrumentation.
• Experience working with and analysing biomolecules, and/or biosensors.
• Knowledge and experience of orthogonal techniques for measuring antibodies, such as SPR and/or BLI.
• Exceptional problem-solving skills and a creative mind-set.
• Ability to communicate complex scientific ideas.
• Experience preparing technical reports, protocols, SOPs, application notes, and user guides to support product adoption and compliance.

The following would also be advantageous: 

• Working knowledge and familiarity with next generation antibodies, such as bispecifics and ADCs
• Working knowledge of regulatory standards, such as ISO 9001
• Familiarity with Python
• We know there is no such thing as the perfect candidate and that there is great value in transferrable skills, so please don’t feel you have to tick all of the above boxes to apply!

Why work for Refeyn?

Compensation and core benefits

• We anticipate a base salary of £40,000 to £65,0000 for this role, depending on candidate experience 
• 25 days annual leave per year in addition to bank holidays
• Up to 7% employer matched pension contribution
• Private health insurance plus Medicash, critical illness cover, income protection and life insurance
• Give as You Earn and Cycle to Work salary sacrifice schemes.
• Annual Company and Individual bonus scheme 
• Paid volunteer day each year

Family Friendly Benefits

Refeyn offers YellowNest Nursery Scheme to all employees once probation is passed, and new parents can benefit from up to 17 weeks fully paid maternity, adoption and shared parental leave, 4 weeks fully paid paternity leave, plus an annual allowance for emergency childcare.

Supporting your Development

All employees receive access to Linkedin Learning which offers thousands of courses to support their personal and professional development. We also run frequent training sessions on both hard and soft skills.

Creating an Engaging Culture

Refeyn supports hybrid working where the role allows and offers flexible start and finish times. We also have a subsidised weekly lunch for onsite employees and a vibrant social calendar which includes holiday parties and midsummer festivals plus an annual team budget for managers to plan team-building activities.

Values-Led 

Refeyn is committed to celebrating each other’s differences and creating a dynamic, driven and diverse culture where everyone can flourish. We are proud to have been awarded Committed Status by the Inclusive Employers Standard in 2024 and are working hard to create a safe and empowering environment for all.

We firmly believe that there is great strength in building teams with different voices, experiences, perspectives, and backgrounds so that we can continue to share the team workload and enable our customers to succeed, and we welcome applicants from all sections of society to join us on our mission to advance discovery through innovation. 

Expected Interview Plan

• Initial Teams call with the hiring manager (30 minutes)
• Onsite panel interview with presentation and site tour (90 minutes)
• Final call with Chief Product and Marketing Officer (30 minutes)