Avalo Therapeutics

Develops IL-1beta-targeting biologics for inflammation

Senior Scientist - Translational Medicines & Biomarkers

Quantitative Biology & BiostatisticsConfirmed live in the last 24 hours

ContractChesterbrook, PA, USANo salary listedIn-person

About the Job

Requirements

PhD or advanced equivalent degree in immunology, molecular biology, biomedical engineering, or a related discipline.
5–8 years of experience in pharmaceutical development or translational clinical research, specifically in the immune-mediated and inflammatory disease space.
Experience with hands-on programming for single-cell RNA sequencing and protein biomarker analysis, including statistical and machine-learning knowledge, is a significant advantage.
Strong understanding of in-vitro cell-based assays and in-vivo inflammatory disease models.
Ability to integrate complex data from multiple sources.
Demonstrated ability to independently develop and communicate scientific conclusions and recommendations.
Experience working with cross-functional clinical-development teams.
Strong scientific writing skills.
Ability to manage multiple programs and priorities in a dynamic biotechnology environment.
Scientific independence.
Strong analytical and critical-thinking skills.
Ability to move from data to conclusions and recommendations.
Ability to identify the most decision-relevant scientific questions.
Attention to data quality and analytical rigor.
Ability to operate effectively with incomplete or evolving information.
Strong collaboration and communication skills.
Ability to balance strategic thinking with hands-on execution.
Ownership, accountability, and urgency.
Ability to manage several programs simultaneously.

Responsibilities

Develop and implement biomarker and translational strategies for clinical-development programs.
Identify pharmacodynamic and potentially predictive, prognostic, and patient-stratification biomarkers.
Provide immunoassay input, including pharmacokinetic and pharmacodynamic considerations, into clinical protocols and sampling schedules.
Ensure biomarker plans address the key clinical-development questions for each program.
Evaluate assay readiness, feasibility, validation requirements, and sample-handling considerations.
Lead or support analysis of clinical biomarker datasets.
Integrate biomarker results with efficacy, safety, pharmacokinetic, anti-drug antibody, neutralizing antibody, and patient-characteristic data to generate a clear pharmacodynamic picture.
Evaluate response-associated biomarkers, disease subgroups, and potential confounding factors.
Distinguish exploratory signals from robust and biologically meaningful findings.
Develop scientific conclusions and recommendations, and identify additional analyses needed to address emerging questions.
Evaluate target biology, mechanisms of action, and disease rationale.
Develop translational plans for early-development programs.
Design or recommend experiments to test key mechanistic hypotheses.
Oversee contract research organizations, including assay design, assay execution, and raw-data analysis.
Support candidate-selection and indication-selection decisions.
Work with stakeholders to ensure program success.
Collaborate with contract research organizations, bioanalytical laboratories, consultants, and academic experts.
Represent Translational Medicine and Biomarkers in program-team meetings.
Communicate complex scientific findings clearly to scientific stakeholders.
Prepare internal data-review presentations and program recommendations.
Conduct literature reviews and competitive-landscape assessments.

Desired Qualifications

Experience with monoclonal antibody development.
Experience in hidradenitis suppurativa, inflammatory diseases, rheumatology, dermatology, or autoinflammatory diseases.
Familiarity with cytokine biology and immune-pathway modulation.
Experience with multiplex biomarker platforms.
Experience with exploratory statistical analyses and biomarker-subgroup analyses.
Hands-on programming of large datasets is a significant advantage.
Experience managing contract research organizations and external bioanalytical laboratories.

At Avalo (ahh-vah'-low), we are 100% focused on developing treatments for immune-mediated inflammatory diseases with large unmet needs that affect millions worldwide. Our strategy is to develop medicines that target the IL-1β pathway, which is a central driver of the inflammatory process.

We share a commitment to teamwork, passion for science, and dedication to patients suffering from acute and chronic inflammatory disorders. Our collective expertise in discovery, development, and regulatory approvals is evidenced in our strong individual track records of advancing multiple therapeutic programs to successful commercialization.

This is a contract/Contract to hire position.

Position Summary:

The Senior Scientist ,Translational Medicines & Biomarkers will provide scientific leadership and support across clinical and preclinical development programs.

The successful candidate will be responsible for developing and executing translational and biomarker strategies, interpreting biomarkers data integration with PK, PD, ADA, NAb, efficacy, and safety data, and supporting the advancement of clinical-stage and early pipeline programs.

This role requires a scientist who can independently analyze complex datasets, develop scientifically rigorous conclusions, and communicate actionable recommendations to multidisciplinary teams and senior leadership.

Essential Duties and Responsibilities:

Clinical biomarker and translational strategy

Develop and implement biomarker and translational strategies for clinical-development programs
Identify pharmacodynamic and potentially predictive, prognostic, and patient-stratification biomarkers
Provide immunoassays (including PK and PD) input into clinical protocols and sampling schedules.
Ensure that biomarker plans address the key clinical-development questions for each program
Evaluate assay readiness, feasibility, validation requirements, and sample-handling considerations

Clinical-data analysis and interpretation

Lead or support analysis of clinical biomarker datasets
Integrate biomarker results with efficacy, safety, PK, ADA, NAb, and patient-characteristic data to generate a clear PD picture
Evaluate response-associated biomarkers, disease subgroups, and potential confounding factors
Distinguish exploratory signals from robust and biologically meaningful findings
Develop clear scientific conclusions and recommendations
Identify additional analyses required to address emerging questions

Early pipeline Support

Evaluate target biology, mechanisms of action, and disease rationale

Develop translational plans for early development programs
Design or recommend experiments to test key mechanistic hypotheses
Lead CRO oversights, including assay designs, assays executions and raw data analysis.
Support candidate-selection and indication-selection decisions

Cross-functional collaboration

Work closely with all stakeholders to ensure program success
Collaborate with CROs, bioanalytical laboratories, consultants, and academic experts
Represent Translational Medicine and Biomarkers in program team meetings
Communicate complex scientific findings clearly to scientific stakeholders

Scientific communication

Prepare internal data-review presentations and program recommendations
Conduct literature reviews and competitive landscape assessments

Required Education and Experience:

PhD or advanced equivalent degree in immunology, molecular biology, biomedical engineering or a related discipline
5-8 years of experience in pharmaceutical development, or translational clinical research, specifically in the I&I space
Experience in hands-on programming for single cell RNA-seq and protein biomarkers analysis including statistics and machine learning knowledge- significant advantage.
Strong understanding in in-vitro cell-based assays, and in-vivo inflammatory diseases models
Ability to integrate complex data from multiple sources
Demonstrated ability to independently develop and communicate scientific conclusions and recommendations
Experience working with cross-functional clinical-development teams
Strong scientific writing skills
Ability to manage multiple programs and priorities in a dynamic biotechnology environment

Preferred Qualifications

Experience with monoclonal antibody development
Experience in hidradenitis suppurativa, inflammatory diseases, rheumatology, dermatology, or autoinflammatory diseases
Familiarity with cytokine biology and immune-pathway modulation
Experience with multiplex biomarker platforms
Experience with exploratory statistical analyses and biomarker-subgroup analyses
Hands-on programming of large datasets – a significant advantage
Experience managing CROs and external bioanalytical laboratories

Additional Skills, Knowledge, And/or Abilities:

Scientific independence
Strong analytical and critical-thinking skills
Ability to move from data to conclusions and recommendations
Ability to identify the most decision-relevant scientific questions
Attention to data quality and analytical rigor
Ability to operate effectively with incomplete or evolving information
Strong collaboration and communication
Ability to balance strategic thinking with hands-on execution
Ownership, accountability, and urgency
Ability to manage several programs simultaneously

About Avalo Therapeutics

Avalo Therapeutics is a clinical stage biotechnology company dedicated to developing therapeutics targeting the IL-1β pathway for immune-mediated inflammatory diseases. Avalo is advancing its lead anti-IL-1β monoclonal antibody (mAb) drug candidate, abdakibart, into a phase 3 registrational program in hidradenitis suppurativa (HS), a chronic inflammatory skin condition that affects an estimated 1–4% of the population globally. Avalo is pursuing additional development opportunities in IL-1β driven indications. Avalo is also developing AVTX-010, a long-acting next-generation anti-IL-1β mAb. For more information about Avalo, please visit www.avalotx.com.

ATTENTION: External Agencies and Placement Firms

A member of the Avalo Human Resources Department will contact an agency directly if an open position is eligible to be sourced from an outside recruiting service. Avalo does not accept unsolicited resumes from employment agencies for any employment opportunity. All agencies/recruiters must have a written agreement/SOW in place with Avalo and prior to submitting any resume or CV.

All resumes must be submitted through the appropriate process. Any resumes submitted without an agreement and/or any resumes sent unsolicited through e-mail accounts of Avalo employees will be considered outside of the appropriate process, do not imply or create any obligation on our part, do not impart any restrictions on Avalo with respect to the hiring of any persons whose resumes are so submitted and are not eligible for placement fees.

About the Company

Avalo Therapeutics

Develops IL-1beta-targeting biologics for inflammation

Avalo Therapeutics develops biologic therapies that target the IL-1beta pathway for immune-mediated inflammatory diseases. Its lead candidate, abdakibart (AVTX-009), is a humanized monoclonal antibody that inhibits IL-1beta and blocks downstream inflammatory signaling, advancing toward a registrational Phase 3 program after positive Phase 2 results in hidradenitis suppurativa. AVTX-010 is a long-acting next-generation anti-IL-1beta antibody designed to extend dosing intervals. The company focuses on research and development of novel biologics with commercialization expected through pharmaceutical partnerships and product sales. Unlike some competitors that pursue broader or different inflammatory targets, Avalo concentrates specifically on IL-1beta–related inflammation with a pipeline aimed at improving dosing convenience and clinical outcomes in inflammatory diseases.

Company size: 51-200
Company stage: IPO
Headquarters: Rockville, MD
Founded: 2011

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