Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Senior Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

• Participate in the discovery of novel inhibitors of frontier oncology targets by planning and implementing DMPK strategies to drive key project decisions for advancing small molecule programs.

• Represent DMPK functional area on multi-disciplinary teams. Develop, design, and manage the ADME/PK studies at CROs in a timely manner, and present results at internal cross-functional meetings.

• Generate hypotheses from available data and literature, conduct innovative research to understand the principles of drug distribution and elimination, PKPD relationships, and DDI risk potential.

• Incorporate new concepts, experimental techniques, and mathematical models into human PK and dose predictions and implement the preclinical strategy for predicting human efficacious exposure ranges and safety margins.

• Conduct IND enabling studies at CROs, author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.

• Build and maintain strong collaborative partnerships across functional areas, e.g., Biology/Cancer Pharmacology, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.

Required Skills, Experience, and Education:

• A highly motivated individual with a PhD in Pharmaceutic Sciences or a related scientific discipline, with 3-5 years industry experience.

• Understanding of ADME principles, hands-on experience in conducting in vitro and in vivo ADME/PK assays.

• Solid knowledge and experience in the application of PK and basic compartmental modeling software.

• Excellent verbal and written communication, problem-solving and critical thinking skills.

• Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment.

Preferred Skills:

• Prior experience with small molecule drug discovery programs (in the field of oncology drug development or CNS program is a plus).

• Experience working as a DMPK functional representative on cross-functional project teams.

The expected salary range for this role is $150,000 to $190,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in the role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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