Associate Scientist
Manifold Bio
Associate Scientist
Manifold Bio
In vivo precision biologics design platform
Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
We are seeking an exceptional Associate Scientist with hands-on expertise in adeno-associated virus (AAV) vector production, purification, and analytical characterization to join our team. In this role, you will contribute end-to-end to the generation of high-quality, well-characterized AAV lots that enable both rodent and non-human primate (NHP) in vivo studies. You will scale transient transfection, optimize downstream purification processes (affinity chromatography, ion exchange, tangential-flow filtration), and perform key characterization assays (qPCR/ddPCR, ELISA, HPLC, SDS-PAGE, western blot, CGE, endotoxin, sterility). You will be responsible for processing ex-vivo tissues and preparing samples for NGS analysis. You will work closely with molecular biology, protein engineering, in vivo pharmacology to ensure timely delivery of qualified vector lots.
This Role Might Be Perfect For You If
If you’re excited to build the high-quality AAV vectors that power large-scale in vivo screening of novel protein designs, and to contribute directly to our mission of advancing breakthrough treatments, please apply!
Base Salary Range: $100,000-$115,000
This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.
This role is eligible for:
Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
In vivo precision biologics design platform
Manifold Bio creates precision biologics by designing drugs inside living organisms. Its in vivo drug design platform uses a proprietary mCodes protein barcoding system to multiplex multiple proteins in one experiment, enabling pooled in vivo testing of complex biologics. This makes it easier to study and optimize large, biologic drugs in a living system rather than in a test tube. The company differentiates itself as the first to offer an in vivo design platform powered by protein barcodes, allowing researchers to test many proteins at once and streamline drug discovery for complex biologics. Its goal is to expand its in vivo design platform and license or partner its technology with other pharmaceutical and biotech companies to develop new therapeutics.
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