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TWST jumps as Twist Bioscience lands Lilly AI drug discovery deal. MATT MONACO - UPDATED SEP. 19, 2026, 11:07 AM ET Twist Bioscience Corporation stocks have been trading up by 7.1 percent following highly positive sentiment around its latest developments. What traders need to know. * Twist Bioscience signed an agreement to provide antibody characterization data and services to Eli Lilly's AI/ML drug discovery platform, TuneLab, integrating its wet-lab protocols into Lilly's AI models. * Shares of TWST rose, in some reports by more than 4%, after the Lilly TuneLab antibody characterization data services agreement was announced. * Leerink raised its price target on Twist Bioscience from $120 to $160 and reiterated an Outperform rating, leaning on a large, early-stage AI drug discovery opportunity. * UBS initiated coverage of TWST with a Neutral rating and a $144 price target within a broader life science tools initiation that sees the sector outgrowing global GDP over time. * The company said its pilot work on AI-designed mini-binder proteins for Anthropic is already "probably sort of" embedded in its fiscal 2027 orders outlook, not incremental to current guidance. Weekly Update Sep 14 - Sep 18, 2026: On Saturday, September 19, 2026 Twist Bioscience Corporation stock [NASDAQ: TWST] is trending up by 7.1%! Discover the key drivers behind this movement as well as its expert analysis in the detailed breakdown below. Healthcare industry expert: Analyst sentiment - positive Twist Bioscience occupies a differentiated position in synthetic DNA and antibody discovery, with strong 52% gross margins and nearly 10% three-year revenue CAGR off a $377M base, but remains structurally loss-making (EBIT margin ~-32%, ROE ~-30%). Cash burn is material: Q3 free cash flow was -$8.6M despite positive $1.1M operating cash flow largely driven by $18M stock-based comp. Balance sheet risk is contained near term, with current ratio 2.7 and modest leverage (total debt/equity 0.21). The stock is in a powerful short-term uptrend: from $133.41 close on 9/14 to $166.60 on 9/18, with successive higher highs and no material intraday reversals, indicating aggressive buying following the news flow. The 9/17-9/18 range ($155-167) is the new control zone; $155 emerges as first meaningful support and a clear risk-management line. For active traders, pullbacks toward $155 with stabilizing intraday volume offer high-reward entries, targeting a retest and extension above $170. Lilly TuneLab and Anthropic mini-binder work firmly position Twist at the intersection of synthetic biology and AI drug discovery, a structural growth vector well ahead of the broader Healthcare and Diagnostics & Screening groups. The Leerink PT hike to $160 and UBS's $144 initiation validate institutional demand for the AI narrative despite ongoing losses. I see the risk-reward skewed favorably: accumulate on dips toward $155 support, with a 6-12 month upside target zone of $185-$200 and technical resistance beginning near $175. Quick financial overview. Twist Bioscience Corporation is trading in a strong upswing, with the weekly chart showing a move from $133.41 to $166.60 over the recent data window. That is a sharp multi-day leg higher, reinforced by intraday action where price ran from an open near $158 to a session high above $167 before closing just under that high. For short-term traders, that is classic momentum behavior: buyers in control, shallow intraday pullbacks, and a close near the top of the day's range. The Lilly TuneLab agreement is driving this surge, as TWST locks its antibody characterization workflows directly into Eli Lilly's AI/ML drug discovery platform. Multiple reports tie the share price pop, including gains of more than 4% on one session, to this AI collaboration. On the Street side, Leerink lifting its price target from $120 to $160 with an Outperform call, and UBS coming in at $144 with a Neutral, both anchor expectations well above prior averages and help explain why traders are willing to chase strength. Under the hood, Twist Bioscience generated about $376.57M in revenue over the trailing period, with a healthy 52% gross margin but deep negative profitability metrics, including an EBIT margin near -31.8% and returns on equity around -29%. The latest quarterly report (period ending 2026/06/30) shows $118.38M in revenue but a net loss of roughly $35.05M and EBITDA of about -$27.96M, although operating cash flow turned slightly positive at $1.12M. Balance sheet strength is reasonable for a high-growth name, with a current ratio of 2.7 and total debt to equity at 0.21, but valuation is rich, with price-to-sales around 23.89 and price-to-book over 23, which helps explain why some analysts stay cautious even as they set high absolute targets. Conclusion. This is stock news, not investment advice. Timothy Sykes News delivers real-time stock market news focused on key catalysts driving short-term price movements. Its content is tailored for active traders and investors seeking to capitalize on rapid price fluctuations, particularly in volatile sectors like penny stocks. Readers come to Millionaire Media, LLC. for detailed coverage on earnings reports, mergers, FDA approvals, new contracts, and unusual trading volumes that can trigger significant short-term price action. Some users utilize its news to explain sudden stock movements, while others rely on it for diligent research into potential investment opportunities. Dive deeper into the world of trading with Timothy Sykes, renowned for his expertise in penny stocks. 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Twist Bioscience shares surged roughly 9% on Thursday to close near $156, hitting a multi-year high and pushing the synthetic-DNA company's market cap above $10 billion. The rally followed a partnership with Eli Lilly's TuneLab AI platform and a price target increase from Leerink to $160 from $120. Twist sells custom-made DNA to research labs and drugmakers. Last month, the company raised its full-year fiscal 2026 sales guidance to $456 million–$457 million and said it aims to break even on adjusted earnings in the fourth quarter. Former hedge fund manager Martin Shkreli called the stock a short on social media despite the gains. Twist shares have climbed approximately 390% year-to-date.

Lilly TuneLab, Twist Bioscience partner on antibody drug discovery. Twist will provide antibody characterization data services for TuneLab, allowing users to generate high-quality wet lab data. September 16, 2026 Content Marketing Editor Editor's Take: Linking experimental data to AI-enabled discovery can potentially result in acceleration of antibody drug discovery. Lilly TuneLab, an artificial intelligence/machine learning (AI/ML) drug discovery platform from Eli Lilly and Company, is partnering with Twist Bioscience. Twist is a mid-cap growth and value biotech company. How Twist interfaces with TuneLab. The agreement centers on Twist providing antibody characterization data services for TuneLab - including for AbLab, an antibody developability prediction model. In short, users can order antibody services from Twist using TuneLab preferred Twist protocols, to generate high-quality wet lab data. TuneLab's prediction models help participants more rapidly down-select candidate molecules. Overall, the approach links experimental data to AI-enabled discovery - allowing for potential acceleration of antibody drug discovery. Twist Co-Founder and CEO Emily Leproust, PhD, says Twist's scale and high-throughput capabilities generate consistent, reliable antibody characterization data. This caliber of data, Leproust explains, is what AI models should be trained on. "The quality of an AI model's output depends on the quality of the data used to train it," Leproust said. "Lilly's leadership in empowering AI-enabled drug discovery and its impressive network of partnerships create a powerful ecosystem... TuneLab users can select preferred protocols to generate high-quality data with preferred pricing. [This helps] them to more efficiently select antibody sequences against their targets and contribute that data back to TuneLab." Other unique Lilly services. TuneLab, part of Lilly's Catalyze360 suite with Lilly Ventures, Lilly Gateway Labs, and Lilly ExploR&D, exists to accelerate biotech innovation. Participating companies can access AI/ML drug discovery models trained on decades of proprietary Lilly research data. Lilly Catalyze360 as a whole also supports biotech innovation by making available strategic capital, lab space and technology, and R&D. Add us as a preferred source on Google. Get the latest Contract Pharma news, insights and analysis in your Google Search and AI experiences.