Scientist - Lipid Nanoparticle Delivery

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking a Scientist with experience in lipid nanoparticle (LNP) delivery chemistries to join our Epigenetic Editing team. Our Epigenetic Editing team is developing nucleic acid delivery chemistries to enable our therapeutic programs

In this role, you will develop and evaluate LNP formulations for delivery of nucleic acids to hepatocytes, contribute to selecting delivery technologies for our Discovery and Development efforts, and serve as a subject matter expert on LNPs across NewLimit.

As a Scientist on our team, you will:

• Collaborate with our Epigenetic Editing and Metabolism teams to design and implement an LNP delivery strategy for reprogramming interventions
• Formulate lipid nanoparticles for nucleic acid delivery to hepatocytes in a variety of model systems, including humanized liver models
• Engineer lipid nanoparticles with targeting moieties to promote cell type-specific delivery
• Serve as the key decision maker for NewLimit’s lipid nanoparticle formulation approach at the Discovery stage
• Analyze and interpret experimental data to drive decision making in Discovery and pre-clinical Development

Requirements

• Ph.D. in Biomedical Engineering, Chemical Biology, Chemical Engineering, or a related disipline or ≥5 years of equivalent industry experience
• Experience formulating lipid nanoparticles with diverse lipid components for nucleic acid delivery
• Experience evaluating lipid nanoparticle quality based on size, nucleic acid loading efficiency, and polydispersity
• Experience with LNP delivery either in vitro or in vivo and associated reporter read-outs

Nice to have

• History of contributing to a drug development program at the pre-clinical or clinical development stage
• Experience with LNP delivery to hepatocytes or a background in liver biology
• Experience modifying LNPs with targeting moieties to engender cell type specificity
• Experience with next-generation sequencing (NGS) and high-throughput experimental systems

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site

Salary Range: $113,000 to $185,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers   *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.