Full-Time
Posted on 8/18/2026
Precision oncology therapies guided by biomarkers
$187k - $231k/yr
Kansas, USA + 3 more
More locations: Iowa, USA | Kansas City, MO, USA | Missouri, USA
Hybrid
Residence within the assigned geographic region is required; travel is approximately 80%, with overnight travel as needed. Onsite training and meetings are required, with work-from-home flexibility.
Bachelor's
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IDEAYA Biosciences develops targeted cancer therapies by combining translational biomarkers with small molecule drug discovery to identify and treat specific patient populations defined by molecular diagnostics. Its product work relies on identifying biomarkers that predict which patients will respond to a given therapy and then designing and optimizing small molecules that target those biology. The company differentiates itself by grounding drug discovery in biomarker-driven precision medicine—mapping patient subgroups to therapies rather than pursuing broad oncology indications—and by pursuing partnerships and licensing to fund R&D and reach commercialization. The goal is to deliver precise, biomarker-guided cancer treatments that improve outcomes for defined patient groups and bring those therapies to market through collaborations and eventual sales of approved drugs.
Company Size
201-500
Company Stage
IPO
Headquarters
San Francisco, California
Founded
2015
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Health Insurance
Dental Insurance
Vision Insurance
Wellness Program
Stock Options
Employee Stock Purchase Plan
Flexible Work Hours
IDEAYA and Genentech Partner to Evaluate IDE892 Plus GDC-7035 in PDAC. IDEAYA and Genentech will evaluate IDE892 with KRAS G12D inhibitor GDC-7035 in MTAP-deleted, KRAS G12D-mutant pancreatic cancer. M.Pharm (Reg. Affairs) IDEAYA Biosciences has entered into a clinical collaboration with Genentech, a member of the Roche Group, to evaluate IDE892, its investigational MTA-cooperative PRMT5 inhibitor, in combination with GDC-7035 (RG6620), Genentech's KRAS G12D inhibitor, in patients with pancreatic ductal adenocarcinoma (PDAC) harboring both MTAP deletion and a KRAS G12D mutation. Under the collaboration, Genentech will sponsor the clinical combination study, while IDEAYA will supply IDE892. The companies will jointly oversee the collaboration through a shared governance structure. Targeting MTAP-Deleted, KRAS G12D-Mutant PDAC. The collaboration focuses on a molecularly defined subgroup of PDAC in which MTAP deletion and KRAS G12D mutations occur together. IDEAYA estimates that these alterations co-occur in up to approximately 15% of patients with PDAC. Patients with tumors carrying both alterations currently have no approved targeted treatment options. IDEAYA stated that combining a PRMT5 inhibitor with a KRAS G12D-specific inhibitor may have the potential to produce deeper and more durable responses in this genetically defined patient population. The new combination therefore brings together two targeted investigational approaches designed to address distinct molecular features of these tumors. IDE892 development program expands. IDEAYA is currently evaluating IDE892 in a Phase 1 study of monotherapy and combination therapy in patients with MTAP-deleted advanced solid tumors (NCT07277413). The company has also initiated a Phase 1 combination cohort evaluating IDE892 with IDE397, its proprietary MAT2A inhibitor, in non-small cell lung cancer and other solid tumors. IDEAYA plans to initiate another Phase 1 combination cohort with Roche's RG6505 in MTAP-deleted, RAS-mutant PDAC during the second half of 2026. The newly announced collaboration adds GDC-7035 as an additional KRAS-directed combination partner within the broader IDE892 development program. According to IDEAYA, the company is pursuing multiple combination strategies for IDE892, including combinations with IDE397, pan-RAS inhibitors, KRAS-mutant-specific therapies, and its lead CDKN2A compound. IDE892 shows potential best-in-class characteristics. IDEAYA reported that IDE892 has approximately 1,400-fold selective MTA-PRMT5 cooperative binding compared with SAM-PRMT5 cooperative binding. The company also reported that IDE892 was designed to lack brain penetration, with the aim of maximizing its therapeutic window. These properties are intended to support the development of IDE892 in combination with other targeted therapies, including MAT2A inhibitors, pan-RAS inhibitors, KRAS-directed therapies, and CDKN2A-directed approaches. IDEAYA also reported that IDE892 has a CYP3A4 IC50 greater than 45 micromolar and did not demonstrate time-dependent inhibition across the seven major cytochrome P450 enzymes: CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. The findings were based on full kinetic CYP inactivation assays. According to IDEAYA, these drug-interaction characteristics may further support the development of IDE892 as a combination partner for targeted therapies. Terms of the collaboration. Under the clinical collaboration, IDEAYA and Genentech will each retain all commercial rights to their respective compounds, including their use as monotherapies and in combination regimens. Genentech will sponsor the clinical combination study, while IDEAYA will provide IDE892. The companies will maintain joint governance over the clinical supply collaboration and conduct of the study. Clinical significance. The collaboration will evaluate IDE892 in combination with Genentech's KRAS G12D inhibitor GDC-7035 within Genentech's Phase I/II clinical program (NCT06619587), which is evaluating GDC-7035 as a single agent and in combination with other anticancer therapies in patients with KRAS G12D-mutant advanced solid tumors. The new collaboration will specifically assess the combination in patients with PDAC harboring both MTAP deletion and a KRAS G12D mutation. The agreement also expands IDEAYA's strategy of evaluating IDE892 across multiple rational combination approaches in molecularly selected cancers. Reference. About the Writer Kalyani Boharapi (LinkedIn) is a pharmacy professional and healthcare writer currently pursuing an M.Pharm in Regulatory Affairs at Dr. D. Y. Patil College of Pharmacy, with interests in pharmaceutical regulations, drug development, and healthcare innovation. She has academic exposure to dossier preparation, scientific writing, and regulatory documentation. Kalyani has also completed certification courses in Generative AI, AI in Pharma, and Bioinformatics, and actively participates in pharmaceutical conferences to stay updated with emerging trends and advancements in the healthcare and pharmaceutical industry.
LifeSci Capital sticks to its Buy rating for IDEAYA Biosciences (IDYA). Aug. 8, 2026, 08:35 AM LifeSci Capital analyst Charles Zhu maintained a Buy rating on IDEAYA Biosciences today and set a price target of $58.00. * Unlock powerful investing tools with TipRanks Premium to make smarter, more confident investment decisions * Subscribe to TipRanks Smart Investor Newsletter, and discover new investing opportunities with data-backed stock picks Zhu covers the Healthcare sector, focusing on stocks such as Revolution Medicines, Kura Oncology, and IDEAYA Biosciences. According to TipRanks, Zhu has an average return of 25.9% and a 63.60% success rate on recommended stocks. IDEAYA Biosciences has an analyst consensus of Strong Buy, with a price target consensus of $51.91. Based on IDEAYA Biosciences' latest earnings release for the quarter ending June 30, the company reported a quarterly revenue of $8.86 million and a GAAP net loss of $112.45 million. In comparison, last year the company had a GAAP net loss of $77.49 million Read More on IDYA:
IDEAYA Biosciences announces Yujiro S. Hata elected Chairman of its Board of Directors. SOUTH SAN FRANCISCO, Calif., June 17, 2026 /PRNewswire/ - IDEAYA Biosciences, Inc. (NASDAQ: IDYA), a leading precision medicine oncology company, today announced that its Board of Directors has elected Yujiro S. Hata, Chairman of the Board. Mr. Hata is currently President and Chief Executive Officer, and a member of IDEAYA's Board. Terry Rosen, Ph.D., will serve as Lead Independent Director of IDEAYA's Board. "On behalf of the Board of Directors, I would like to congratulate Yujiro on this Chair appointment," said Dr. Terry Rosen, Lead Independent Director, IDEAYA Biosciences. "Since founding IDEAYA over a decade ago, Yujiro's vision, passion for the mission, and leadership have been core to the evolution of IDEAYA from an early science-driven start-up to a leading precision medicine oncology company with an extensive clinical pipeline where commercial launch preparations are underway." "I am grateful to the board for the opportunity to serve and advance IDEAYA's vision to drive forward our important cancer research and deliver breakthrough therapies for patients to address high unmet medical needs in cancer," said Yujiro S. Hata, President and Chief Executive Officer, IDEAYA Biosciences. About IDEAYA Biosciences IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Its approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. Ideaya Biosciences Inc. has built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Its mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. Forward-Looking Statements This press release contains forward-looking statements, including, but not limited to, statements related to IDEAYA's vision, strategy, mission, future growth, advancement of its research programs, development and potential commercialization of its product candidates, preparations for potential commercial launches, and the ability to deliver breakthrough therapies to patients with cancer and address unmet medical needs. Such forward-looking statements are based on management's current expectations, assumptions and beliefs and involve substantial risks and uncertainties that could cause actual results, including, but not limited to, those related to IDEAYA's clinical programs, commercial activities, and performance and/or achievements, to differ significantly and/or materially from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including the process of designing and conducting preclinical and clinical trials, enrollment rates, safety outcomes, efficacy results, regulatory interactions and decisions, and the ability to translate preclinical findings into clinical benefit, manufacturing and supply risks, competition, changes in standard of care, the timing and success of commercialization efforts, the outcome of collaborations and licensing arrangements, IDEAYA's ability to successfully establish, protect and defend its intellectual property, and other matters that could affect the sufficiency of financial resources to fund operations. IDEAYA undertakes no obligation to update or revise any forward-looking statements. A further description of risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of IDEAYA in general, are in IDEAYA's filings with the Securities and Exchange Commission, including IDEAYA's most recent Annual Report on Form 10-K and any current and periodic reports filed with the U.S. Securities and Exchange Commission. Investor and Media Contact IDEAYA Biosciences Joshua Bleharski, Ph.D. Chief Financial Officer [email protected] SOURCE IDEAYA Biosciences, Inc.
IDEAYA Biosciences has enrolled the first patient in a Phase 1/2 clinical trial evaluating IDE892, an MTA-cooperative PRMT5 inhibitor, combined with IDE397, a MAT2A inhibitor, for MTAP-deleted pancreatic and lung cancers. MTAP deletion occurs in up to 40% of pancreatic cancers and approximately 15% of non-small cell lung cancer. IDE892 demonstrates favourable drug-like properties, including a CYP3A4 IC50 exceeding 45 micromolar and no time-dependent inhibition of major cytochrome P450s. The company's Phase 1 monotherapy escalation has cleared multiple dose cohorts without reaching maximum tolerated dose, with expansion anticipated in Q3 2026. Preclinical studies showed dual PRMT5 and MAT2A inhibition produced potent anti-tumour activity in MTAP-deleted models. IDEAYA is also collaborating with Roche to evaluate IDE892 with pan-RAS inhibitor RG6505 in pancreatic cancer.
/PRNewswire/ -- IDEAYA Biosciences, Inc. (Nasdaq: IDYA) today announced the closing of its underwritten public offering of 7,222,225 shares of its common stock...