Research Associate

Position Summary: 

The Research Associate will support Research and Development activities in the field of molecular biology, with a focus on the identification and verification of DNA methylation-based biomarkers and the development, optimization, and verification of epigenetic qPCR assays and ddPCR-based assays. The position involves the execution of laboratory experiments, processing of clinical study samples, analysis and documentation of experimental data, and support of laboratory quality and operational activities in a regulated environment.

Essential functions of the job include but are not limited to:

• Perform laboratory activities in accordance with approved SOPs, work instructions, and experimental protocols with appropriate guidance.
• Conduct laboratory experiments to support the identification and verification of DNA methylation-based biomarkers.
• Support the development, optimization, verification, and transfer of (epigenetic) qPCR- and ddPCR-based assays.
• Perform experimental quality control activities and support the qualification and release of plasmid standards and other critical reagents.
• Receive, prepare, process, and document clinical trial samples in accordance with defined procedures and study requirements.
• Perform epigenetic immune monitoring analyses, including bisulfite conversion and purification of DNA samples, qPCR analysis, data evaluation, and quality control.
• Analyze, interpret, document, and communicate experimental results to project scientists and team members.
• Identify technical issues, investigate deviations, and support troubleshooting and root cause analysis activities.
• Prepare reagents, controls, and laboratory materials required for routine and development activities.
• Operate and maintain laboratory automation and liquid handling systems.
• Perform routine equipment checks, maintenance, calibration support, and associated documentation activities.
• Maintain accurate, complete, and traceable laboratory records in accordance with applicable quality requirements.
• Support the preparation, review, and revision of SOPs, work instructions, protocols, reports, and other controlled documents.
• Participate in method evaluations, feasibility studies, and implementation of new laboratory technologies.
• Collaborate with scientists, project managers, and laboratory personnel to meet project timelines and milestones.
• Support laboratory organization, inventory management, ordering of consumables, and monitoring of laboratory supplies.
• Perform all activities in accordance with applicable health, safety, quality, and data integrity requirements.
• Contribute to inspection and audit readiness activities.

Qualifications:

Minimum Required:

• Bachelor’s Degree in Molecular Biology, Biology, Biochemistry, Biotechnology, Life Sciences, or a related scientific discipline.
• Minimum of 2 years of relevant laboratory experience or an equivalent combination of education and experience.
• Practical experience with molecular biology laboratory techniques.
• Experience working with scientific procedures, protocols, and laboratory documentation.
• Ability to communicate effectively in English, both written and verbal.
• German language skills at a minimum B1 level.
• Proficiency with Microsoft Office applications, particularly Excel and Word.

Other Required:

• Ability to organize, prioritize, and manage multiple tasks simultaneously.
• Structured, reliable, and quality-focused working style.
• Ability to work effectively both independently and within a multidisciplinary team.
• Good analytical and problem-solving skills.
• Ability to evaluate experimental data and document results appropriately.
• Willingness to continuously learn new methods, technologies, and quality system requirements.

 Preferred:

• Experience with DNA methylation analysis and bisulfite conversion methods.
• Experience with qPCR and/or ddPCR technologies.
• Experience processing and handling clinical trial samples.
• Experience with assay development, optimization, verification, or validation.
• Experience operating automated liquid handling systems.
• Experience with Laboratory Information Management Systems (LIMS).
• Familiarity with GraphPad Prism or other scientific data analysis software.
• Experience working in a regulated or quality-controlled laboratory environment (e.g., GCP, GLP, ISO, CAP, CLIA, or equivalent).
• Knowledge of cell biology and immunology concepts.
• Experience supporting scientific reports, technical documentation, or publications.