Postdoctoral Scholar

Department Overview

The Gibbs and Wang Laboratories in the Department of Biomedical Engineering at Oregon Health & Science University (OHSU) in Portland, Oregon are recruiting a postdoctoral fellow to work on projects focused on multiplexed fluorescence imaging, cyclic immunofluorescence, quantitative image analysis, and spatial biology in tissue and blood samples.

Our team is developing quantitative fluorescence imaging technologies to measure cellular phenotypes, biomarker expression and spatial relationships within complex biological samples. Current projects include high-plex cyclic immunofluorescence of tissues, quantitative analysis of circulating cells in blood, and development of computational approaches to extract molecular and spatial information from large imaging datasets. These studies span cancer biology, biomarker discovery, disease progression and translational molecular imaging.

The Gibbs and Wang Laboratories are well supported by NIH and foundation funding and provide a collaborative environment spanning molecular imaging, fluorescence microscopy, computational analysis, cancer biology and clinical translation.

Function/Duties of Position

• Perform multiplexed immunostaining and related wet-laboratory studies, including cyclic immunofluorescence, antibody conjugation, preparation of tissue and blood samples, and optimization and validation of staining protocols.
• Perform fluorescence microscopy and quantitative image acquisition, including image quality control, experimental optimization and validation of imaging results.
• Develop and apply computational approaches for quantitative analysis of multiplexed imaging data, including image preprocessing, cell segmentation and classification, feature extraction, spatial analysis, statistical modeling, machine learning, and development of reproducible image-analysis workflows.
• Participate in laboratory and project meetings and contribute to manuscripts, figures, data analysis and applications for research funding as appropriate.
• Present research at local, national and international scientific meetings and contribute to dissemination of research findings through publications and other scholarly activities.
• Provide scientific guidance and mentorship to graduate students, undergraduate researchers and other trainees working on related projects, as appropriate.
• Other duties as assigned.

Required Qualifications

• PhD in biomedical engineering, bioengineering, computational biology, bioinformatics, imaging science or a closely related field.

Skills and Abilities

• Experience with quantitative image analysis, computational biology, or analysis of biological imaging data; experience with programming and quantitative data analysis.

• Experience with multiplexed immunofluorescence, cyclic immunofluorescence, fluorescence microscopy, spatial biology, machine learning, tissue or blood imaging or other high-dimensional imaging approaches.

• Must have strong quantitative and computational skills and the ability to independently develop, apply and troubleshoot image-analysis workflows for biological imaging data.

• Must have experience with scientific programming and quantitative data analysis, with the ability to work with large imaging datasets and maintain reproducible computational workflows.

• Must have strong communication skills and the ability to work effectively in a multidisciplinary research team.

• Knowledge of fluorescence microscopy, cell segmentation and classification, spatial analysis, statistical modeling, or machine learning is highly desirable.

• Experience with immunofluorescence, spatial biology, or related wet-laboratory methods is preferred.

Preferred Qualifications

• Training focused on quantitative imaging, computational biology, spatial biology or molecular imaging.

Additional Details

Applicants should submit a cover letter describing their research experience and interests, a curriculum vitae, and contact information for references.

This position is located at OHSU’s south waterfront campus (RLSB and KCRB); work hours are 8am – 5pm with occasional evening and weekend work as needed.

Benefits 

• Healthcare for full-time employees covered 100% and 88% for dependents.
• $50K of term life insurance provided at no cost to the employee.
• Two separate above market pension plans to choose from.
• Paid time off - 208 hours per year, prorated for part-time.
• Extended illness bank - 64 hours per year, prorated for part-time.
• 9 paid holidays per year.
• Substantial Tri-Met and C-Tran discounts.
• Employee Assistance Program.
• Childcare service discounts.
• Tuition reimbursement.
• Employee discounts to local and major businesses.

Why apply to OHSU?

We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact [email protected]