Director, Site and CMC Program Management

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

Position Summary:

The Director, Program Management will provide strategic leadership and operational oversight for Indianapolis site-based and end-to-end CMC programs. This role will serve on the site leadership team, partner with Product Development and Operations leadership, build core program management capabilities, and ensure effective portfolio delivery across process development, supply chain, production, and related functions.

Job Responsibilities:

Program Management Strategic Leadership

• Serve on the Indianapolis site leadership team to drive strategic priorities and ensure alignment with Product Development and Operations leadership.
• Build and lead the Program Management team, including planning capabilities, systems, processes, governance routines, and KPIs to drive execution.
• Ensure CMC portfolio delivery by partnering across global product teams, key functions--process development, supply chain, production, quality, regulatory, engineering, and external partners.
• Translate strategic priorities into integrated plans, timelines, decision points, risk mitigation strategies, and performance reporting.
• Lead prioritization and escalation discussions to align resources, resolve barriers, and maintain focus on business and patient-impact priorities.

End-to-End CMC and Site Program Execution

• Manage integrated CMC program planning and execution across site operations, global program teams, Product Development functions, Quality, Regulatory, Finance, and Commercial stakeholders.
• Coordinate key site and portfolio initiatives, including manufacturing readiness, technology transfer, supply chain planning, engineering projects, CAPA related initiatives, and operational readiness.
• Identify critical path risks, dependencies, resource constraints, and execution barriers; drive mitigation planning and timely escalation.
• Facilitate effective governance forums with clear agendas, decisions, actions, owners, and follow-through.

Team and Capability Building

• Recruit, develop, and manage program management talent to support evolving CMC and site priorities.
• Define PM accountabilities, decision rights, escalation pathways, standards, tools, templates, and ways of working.
• Strengthen program management maturity through critical path analysis, scenario planning, executive communication, governance preparation, and performance tracking.
• Foster a culture of accountability, collaboration, risk management, continuous improvement, and clear communication.

Communication, Governance, and Stakeholder Management

• Prepare concise updates, dashboards, decision materials, and executive communications for site leadership and governance forums.
• Translate complex technical, operational, and portfolio information into clear insights, recommendations, and actions.
• Serve as a bridge across site operations, global program teams, external partners, and enterprise leadership.
• Promote transparency by surfacing risks, issues, decisions, and trade-offs early through appropriate governance channels.

Education and Experience:

• Bachelor’s degree in life sciences, chemistry, engineering, pharmaceutical sciences, business, or related discipline required; advanced degree preferred.
• Minimum of 10 years of pharmaceutical, biotechnology, or related life sciences experience, with significant experience in program/project management and CMC, manufacturing, process development, or site operations.
• Demonstrated experience leading cross-functional, matrixed teams and complex programs with multiple stakeholders, risks, dependencies, and competing priorities.
• Experience supporting CMC execution, manufacturing readiness, technology transfer, supply chain planning, or commercial readiness strongly preferred.
• Experience building program management capabilities, operating models, governance routines, dashboards, systems, and KPIs preferred.
• Prior people management experience preferred.

Skills and Qualifications:

• Strategic, execution-focused leader able to translate portfolio priorities into actionable plans and measurable outcomes.
• Strong understanding of drug development, CMC, manufacturing, supply chain, quality, regulatory, and/or radiopharmaceutical environments.
• Proven ability to influence senior leaders and align cross-functional teams without direct authority.
• Excellent communication, analytical, problem-solving, prioritization, and executive presentation skills.
• Demonstrated ability to build teams, implement tools and processes, and drive continuous improvement in a fast-paced environment.
• Leverages AI to drive program, portfolio, or functional performance through prioritization and scaled adoption

Physical Demands and Work Environment

This role is primarily office-based with occasional travel to site, partner, or manufacturing locations as needed.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Indianapolis - RayzeBio - IN: $203,389 - $246,459


The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. 

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
 

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

​Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [email protected]. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response.

R1605207 : Director, Site and CMC Program Management