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Wave Life Sciences USA

Clinical-stage biotech developing stereopure oligonucleotides

Associate Director/Director - Pathology

Translational Research & Bench BiologyConfirmed live in the last 24 hours
Full-timeLexington, MA, USA

About the Job

Requirements

  • A DVM or equivalent degree and ACVP or ECVP board certification are required.
  • A minimum of 3 years of experience working in pathology within a biotechnology, pharmaceutical, or related research environment is required.
  • Senior-level expertise in toxicologic and/or investigative pathology, with experience generating data that informs portfolio, program, and governance decisions.
  • Experience supporting drug discovery pharmacology, investigative toxicology, mechanism-of-action studies, and development-stage programs.
  • Strong knowledge of GLP regulations, regulatory expectations, pathology peer review, documentation quality, and regulatory readiness.
  • Experience in academic, CRO, biotechnology, or pharmaceutical settings, with demonstrated effectiveness in cross-functional drug development programs.
  • Knowledge of advanced pathology methodologies and digital pathology/image analysis platforms, including IHC, multiplex IHC, ISH, immunofluorescence, H&E/IHC image analysis, multiplexed cell phenotyping, and HALO.
  • Willingness to travel up to 4–5 times annually to CRO sites and partner organizations to support project execution, vendor oversight, and cross-functional alignment.

Responsibilities

  • Provide strategic pathology leadership across pharmacology, investigative pathology, and preclinical safety studies to support target identification, candidate selection, biomarker development, and efficacy assessment.
  • Perform primary pathology reads and peer review of regulatory and non-regulatory studies, ensuring scientific rigor, data integrity, high-quality reporting, and regulatory readiness.
  • Shape study strategy, protocol design, data interpretation, and report content in partnership with toxicology, discovery, CRO, and technical teams.
  • Serve as the accountable Project Pathologist for assigned targets, therapeutic areas, and development programs.
  • Partner across functions to evaluate candidate risk, investigate mechanisms of pharmacology and toxicity, and guide risk mitigation strategies.
  • Advance digital and translational pathology capabilities, including image analysis algorithms and biomarker-focused approaches.
  • Contribute to scientific innovation and external visibility through cross-functional collaboration, external engagement, and publications.
  • Communicate pathology strategy, study results, and actionable recommendations to scientific, project, and leadership audiences.
  • Lead and prioritize multiple concurrent programs while maintaining scientific quality, timeline discipline, and stakeholder alignment.

Desired Qualifications

  • A PhD in Pathology, Toxicology, Immunology, or a related discipline is preferred.
  • Expertise in oligonucleotide therapeutics, including antisense oligonucleotides and siRNAs, is preferred.

About the Company

Wave Life Sciences USA

Clinical-stage biotech developing stereopure oligonucleotides

Wave Life Sciences develops stereopure nucleic acid therapies for genetically defined diseases. Its PRISM platform designs stereopure oligonucleotides that enable RNA interference, antisense silencing, splicing modulation, and RNA editing, including AIMers that recruit ADAR enzymes to edit RNA without changing the DNA. The company funds R&D mainly through partnerships and licensing (notably with GSK) and has programs in conditions like Alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy, Huntington’s disease, and obesity. Its goal is to bring approved RNA medicines to patients by advancing a diversified pipeline and sustaining long-term collaborations that fund development.

Company size
201-500
Company stage
IPO
Headquarters
Cambridge, MA
Founded
2012

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