Full-Time

Senior Scientist

Medicinal Chemistry

Posted on 4/27/2024

Generation Bio

Generation Bio

51-200 employees

Developing genetic medicines with non-viral delivery

Biotechnology

Senior

Cambridge, MA, USA

Requirements
  • PhD degree in a life sciences discipline with a minimum of 3 years of experience or Master’s with a minimum of 6 years of experience or Bachelor’s with a minimum of 8 years of related experience in an industrial setting
  • Experience optimizing lipid chemistry and conjugation chemistry for nucleic acid delivery is preferred
  • Understanding of lipid nanoparticle formulations for gene therapy products
  • Experience working in collaborative projects and in cross-functional teams
  • Strong communication and organizational skills, and demonstrated ability to operate in a fast-paced environment
  • Results-driven with excellent attention to details
  • Proven ability to effectively plan and organize complex work activities and prioritize task completion to meet schedules and deadlines
  • Proactive thinking and multitasking are essential
Responsibilities
  • Provide technical leadership towards design and synthesis of new chemical entities and custom lipid components aimed at the development of our ctLNP drug product platform
  • Act as a chemistry subject matter expert within the delivery department, and apply those towards advancement of our platform
  • Manage and take ownership of external technical interfaces to contract research organizations (CROs)
  • Work closely with the Pre-clinical, Formulation, Pharmacology, and Biology teams at Generation Bio to advance our understanding of the structure activity relationship of the novel LNP components
  • Formulate and characterize nanoparticle formulations using various physicochemical and in vitro characterization techniques
  • Develop strategies and workflows designed to screen and optimize nanoparticle formulations based on understanding of current technical and pharmacological barriers
  • Support in vivo and in vitro studies to assess the stability and delivery kinetics of LNPs
  • Lead and execute initiatives that contribute to corporate and scientific priorities
  • Lead responsibilities on research strategies, experimental planning, and communication to company leadership and stakeholders
  • Keep clear and transferable records of experiments, update protocols, data summaries to detail development work
  • Provide technical mentorship to junior scientists

Generation Bio

Company Stage

IPO

Total Funding

$536.4M

Headquarters

Cambridge, Massachusetts

Founded

2016

Growth & Insights
Headcount

6 month growth

-20%

1 year growth

-20%

2 year growth

-15%
INACTIVE