Frontier Medicines

Develops precision oncology drugs using chemoproteomics

Vice President Clinical Pharmacology

Quantitative Biology & BiostatisticsConfirmed live in the last 24 hours

Full-timeBoston, MA, USAIn-person

About the Job

Requirements

A PhD, PharmD, or equivalent advanced degree in pharmacology, translational sciences, or a related field is required.
At least 15 years of clinical pharmacology experience in biotech or pharma, including leading clinical pharmacology strategy across clinical trials with oversight of DMPK, is required.
Oncology therapeutic area experience is required.
Strong cross-functional collaboration skills, particularly with Clinical Development, Biometrics, Regulatory Affairs, and CMC, are required.
Demonstrated experience managing CRO and consultant relationships as the primary means of executing clinical pharmacology and DMPK work is required.
Legal authorization to work in the United States is required.

Responsibilities

Lead clinical pharmacology strategy across active clinical trials, including dose selection, dose escalation, dose optimization, and exposure-response analyses.
Oversee nonclinical and clinical bioanalytical strategies and execution.
Oversee DMPK activities in support of clinical and nonclinical program needs.
Provide clinical pharmacology and biopharmaceutics input into CMC decisions, including formulation strategy, bioavailability, and drug-drug interaction risk.
Lead development of clinical pharmacology content for regulatory submissions, including IND/CTA sections and briefing documents, in partnership with Regulatory Affairs.
Represent clinical pharmacology in interactions with the FDA and other health authorities, including Type B/C meetings, briefing document preparation, and responses to information requests.
Apply model-informed drug development approaches, including physiologically based pharmacokinetic (PBPK) modeling and biomarker strategy, to inform dose and development decisions.
Partner with Clinical Development, Biometrics, Regulatory Affairs, and CMC to ensure clinical pharmacology and DMPK considerations are incorporated into trial design and regulatory decisions.
Initially serve as the primary hands-on contributor for clinical pharmacology and DMPK activities, working with CROs and consultants to execute analyses and deliverables; ultimately hire and lead a small internal clinical pharmacology team as the portfolio grows.
Manage CRO relationships supporting clinical pharmacology and DMPK activities.

VP, Clinical Pharmacology

Frontier Medicines · Boston, United States · Full-time · Posted 2026-10-22

Workplace: on_site

Department: Clinical Development

Description

What's in it for you?

Frontier is seeking a VP, Clinical Pharmacology to lead clinical pharmacology strategy across our oncology clinical portfolio. This is a senior, cross-functional leadership role spanning nonclinical pharmacology (PK/PD/ADME and bioanalysis), clinical pharmacology (bioanalysis, dose selection, and PK/PD strategy) for active trials, DMPK oversight, and clinical pharmacology/biopharmaceutics input into CMC decisions.

This individual will serve as Frontier's senior-most clinical pharmacology leader, setting strategy and building out the function and will partner closely with Clinical Development, Regulatory Affairs, Biometrics, and CMC, bringing hands-on scientific expertise to trial design, dose optimization, and regulatory strategy for our oncology programs.

Requirements

What will you be doing?

Lead clinical pharmacology strategy across active clinical trials, including dose selection, dose escalation, dose optimization, and exposure-response analyses.
Oversee nonclinical and clinical bioanalytical strategies and execution.
Oversee DMPK activities in support of clinical and nonclinical program needs.
Provide clinical pharmacology and biopharmaceutics input into CMC decisions, including formulation strategy, bioavailability, and drug-drug interaction risk.
Lead the development of clinical pharmacology content for regulatory submissions, including IND/CTA sections and briefing documents, in partnership with Regulatory Affairs.
Serve as the clinical pharmacology representative in interactions with FDA and other health authorities, including Type B/C meetings, briefing document preparation, and responses to information requests.
Apply model-informed drug development (MIDD) approaches, including PBPK modeling and biomarker strategy, to inform dose and development decisions.
Partner closely with Clinical Development, Biometrics, Regulatory Affairs, and CMC to ensure clinical pharmacology and DMPK considerations are built into trial design and regulatory decisions from the outset.
Serve as the primary hands-on contributor for clinical pharmacology and DMPK activities in the near term, working closely with CROs and consultants to execute analyses and deliverables, and ultimately hire and lead a small internal clinical pharmacology team as the portfolio grows.
Manage CRO relationships supporting clinical pharmacology and DMPK activities.

What are we looking for?

PhD, PharmD, or equivalent advanced degree in pharmacology, translational sciences, or a related field.
15+ years of clinical pharmacology experience in biotech or pharma, including leading clinical pharmacology strategy across clinical trials with oversight of DMPK.
Oncology therapeutic area experience required.
Strong cross-functional collaboration skills, particularly with Clinical Development, Biometrics, Regulatory Affairs, and CMC.
Demonstrated experience managing CRO and consultant relationships as the primary means of executing clinical pharmacology and DMPK work. This role will operate this way initially, before building an internal team.
Comfortable operating in a fast-paced, dynamic environment with a proactive, roll-up-your-sleeves mindset.
Legally authorized to work in the United States.

Benefits

Health Care Plan (Medical, Dental & Vision)
Retirement Plan (401k, IRA)
Life Insurance (Basic, Voluntary & AD&D)
Paid Time Off (Vacation, Sick & Public Holidays)
Family Leave (Maternity, Paternity)
Short Term & Long Term Disability
Training & Development
Free Food & Snacks
Wellness Resources
Stock Option Plan

At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $275,000 - $345,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.

This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.

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About the Company

Frontier Medicines

Develops precision oncology drugs using chemoproteomics

Frontier Medicines develops precision medicines for genetically defined patient populations, mainly in oncology and other hard-to-treat diseases. It uses chemoproteomics, covalent drug discovery, and machine learning to identify small molecules against difficult targets and advances candidates through clinical development toward commercialization. Its lead program FMC-376 targets KRAS G12C in both active and inactive states, and it has built the AutoTAC platform for targeted protein degradation to expand potential drug modalities. The company differentiates itself by combining genetics-driven target selection with advanced proteomics and chemistry within a platform approach that supports partnerships and licensing with larger pharma to bring therapies to patients.

Company size: 51-200
Company stage: Series C
Total funding: $255.5M
Headquarters: South San Francisco, CA
Founded: 2018

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