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Monte Rosa Therapeutics

Develops targeted protein degraders for therapy

Senior Manager, FP&A

Corporate Finance & FP&AConfirmed live in the last 24 hours
Full-timeBoston, MA, USA$130k - $155kIn-person

About the Job

Requirements

  • A bachelor's degree in Finance, Accounting, Economics, or a related quantitative field.
  • Seven to ten or more years of progressive FP&A, corporate finance, or accounting experience.
  • Demonstrated ownership of multiple full budget and forecast cycles for meaningful cost centers, including direct work with senior non-finance leaders.
  • Advanced Excel and financial modeling skills, including the ability to build a clean, auditable, flexible model from a blank sheet.
  • Strong command of accrual accounting and the month-end close process.

Responsibilities

  • Own the annual operating plan, quarterly reforecasts, and long-range plan for assigned areas.
  • Build and maintain driver-based models for headcount, personnel costs, external spend, consumables, capital, and allocations.
  • Prepare monthly and quarterly reporting packages with budget-versus-actual variance analysis, including forward-looking commentary on the full-year outlook.
  • Contribute to cash forecasting, burn analysis, and runway management; support financing planning, Board materials, budget presentations, and external operating expense guidance.
  • Build financial models and decision support for CRO/CDMO and vendor contracts, collaborations, capital equipment, software, and facilities; evaluate resource allocation trade-offs across programs, platforms, and infrastructure.
  • Model headcount plans, compensation cycles, recruiting plans, and payroll and benefits forecasts with People Experience & Operations.
  • Work with Accounting on accruals, reclasses, and spend validation; ensure expense classification follows policy and external reporting requirements.
  • Improve FP&A processes, reporting templates, and self-service reporting in NetSuite and planning tools; support internal controls, SOX-readiness, and audit requests on budgeting and forecasting.

Desired Qualifications

  • Biotech, pharma, or life sciences experience, ideally at a clinical-stage company, with exposure to R&D cost centers.
  • Hands-on experience with NetSuite and an EPM/planning tool such as Adaptive, plus familiarity with public company reporting, including 10-Q/10-K, SOX, and Board reporting.

About the Company

Monte Rosa Therapeutics

Develops targeted protein degraders for therapy

Monte Rosa Therapeutics develops molecular glue degraders (MGDs) to treat cancer and autoimmune/inflammatory diseases using its QuEEN discovery engine, a platform that fuses AI-guided chemistry, proteomics, and structural biology to design MGDs. MGDs work by bringing a target protein together with an E3 ligase, tagging the protein for destruction by the cell's proteasome rather than just inhibiting it. The company distinguishes itself with the QuEEN platform, partnerships with Roche and Novartis for joint development and funding, and a portfolio that includes MRT-2359, MRT-6160, and MRT-8102 as clinical-stage programs. Its goal is to discover, develop, and commercialize MGDs, grow its pipeline, and create value through collaborations, upfront payments, milestones, and royalties while delivering treatments for patients with serious diseases.

Company size
201-500
Company stage
IPO
Headquarters
Boston, MA
Founded
2018

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