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Pulse Biosciences has entered into an at-the-market equity distribution agreement with Mizuho Securities USA for up to $85 million in common stock sales. The company will pay Mizuho a commission of up to 3% of gross sales proceeds. The agreement, announced on 15 September 2026, replaces a previous facility with TD Securities, which was terminated with $1 million in shares remaining unsold. Under an earlier August 2026 agreement with Mizuho, Pulse Biosciences sold 1,379,925 shares, generating approximately $68.8 million in proceeds by 14 September 2026. The shares will be sold through at-the-market offerings on the Nasdaq Capital Market. The company has no obligation to sell shares under the agreement and may suspend offers at any time.

Needham & Company LLC initiates coverage on Pulse Biosciences (NASDAQ:PLSE). August 17, 2026 Key points. * Needham initiated coverage of Pulse Biosciences with a "Buy" rating and a $58 price target, implying approximately 30.22% upside from the reported share price. * Analyst sentiment is mixed but broadly positive: four analysts rate the stock Buy and one rates it Sell, resulting in a "Moderate Buy" consensus and an average price target of $45.25. * Pulse Biosciences missed quarterly expectations, reporting an adjusted loss of $0.36 per share versus the $0.29 consensus estimate and revenue of $0.43 million versus $0.53 million expected; institutional investors own about 76.95% of shares. * MarketBeat previews the top five stocks to own by September 1st. Equities research analysts at Needham & Company LLC initiated coverage on shares of Pulse Biosciences (NASDAQ:PLSE - Get Free Report) in a research note issued on Monday, Marketbeat Ratings reports. The brokerage set a "buy" rating and a $58.00 price target on the stock. Needham & Company LLC's price objective points to a potential upside of 30.22% from the company's current price. Other equities research analysts have also recently issued reports about the stock. Wall Street Zen cut shares of Pulse Biosciences from a "hold" rating to a "sell" rating in a research report on Saturday, August 8th. Oppenheimer reaffirmed an "outperform" rating on shares of Pulse Biosciences in a report on Tuesday, July 28th. Weiss Ratings reiterated a "sell (d-)" rating on shares of Pulse Biosciences in a research report on Friday, July 17th. Mizuho set a $45.00 target price on Pulse Biosciences in a report on Monday, August 10th. Finally, Canaccord Genuity Group upped their target price on Pulse Biosciences from $32.00 to $43.00 and gave the company a "buy" rating in a research report on Monday, August 10th. Four analysts have rated the stock with a Buy rating and one has assigned a Sell rating to the company's stock. Based on data from MarketBeat, Pulse Biosciences has a consensus rating of "Moderate Buy" and a consensus price target of $45.25. Pulse Biosciences stock performance. PLSE stock opened at $44.54 on Monday. Pulse Biosciences has a twelve month low of $12.56 and a twelve month high of $46.97. The company's 50 day moving average is $30.86 and its two-hundred day moving average is $24.74. The stock has a market cap of $3.08 billion, a P/E ratio of -37.75 and a beta of 1.61. Pulse Biosciences (NASDAQ:PLSE - Get Free Report) last issued its quarterly earnings data on Thursday, August 6th. The company reported ($0.36) earnings per share for the quarter, missing the consensus estimate of ($0.29) by ($0.07). Pulse Biosciences had a negative return on equity of 94.42% and a negative net margin of 6,755.78%.The company had revenue of $0.43 million for the quarter, compared to analysts' expectations of $0.53 million. On average, equities research analysts predict that Pulse Biosciences will post -1.29 earnings per share for the current year. Institutional trading of Pulse Biosciences. Institutional investors and hedge funds have recently added to or reduced their stakes in the stock. Jane Street Group LLC purchased a new position in shares of Pulse Biosciences in the 1st quarter valued at approximately $323,000. Creative Planning lifted its holdings in shares of Pulse Biosciences by 26.3% during the second quarter. Creative Planning now owns 18,971 shares of the company's stock worth $286,000 after purchasing an additional 3,951 shares during the period. Legal & General Group Plc lifted its holdings in shares of Pulse Biosciences by 57.7% during the second quarter. Legal & General Group Plc now owns 22,415 shares of the company's stock worth $338,000 after purchasing an additional 8,197 shares during the period. Norges Bank purchased a new position in Pulse Biosciences in the 2nd quarter valued at $302,000. Finally, The Manufacturers Life Insurance Company purchased a new position in Pulse Biosciences in the 2nd quarter valued at $158,000. 76.95% of the stock is owned by hedge funds and other institutional investors. About Pulse Biosciences. Pulse Biosciences, Inc is a clinical-stage bioelectric medicine company that develops and commercializes medical devices based on its proprietary Tissue NanoPoration (TNP) platform. The company's core technology, NanoPulse Stimulation (NPS), delivers ultrashort, high-voltage electric pulses to targeted tissue, triggering cellular responses without the thermal damage associated with traditional energy-based devices. Pulse Biosciences focuses on applications in dermatology and aesthetic medicine, where controlled ablation of unwanted lesions is critical. The company's flagship product, the CellFX(R) System, is designed to treat a range of benign and malignant skin lesions, including seborrheic keratosis, non-melanoma skin cancers, and various epidermal and dermal lesions. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Pulse Biosciences, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Pulse Biosciences wasn't on the list. While Pulse Biosciences currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys.

Pulse Biosciences eyes AFib breakthrough with nanosecond PFA platform. August 16, 2026 Key points. * Pulse Biosciences is advancing nanosecond pulsed field ablation (nsPFA) as a non-thermal platform for atrial fibrillation and other treatments, with roughly 250 patents supporting its technology. * The company is enrolling its U.S. Nano-Pulse AF IDE trial after promising European feasibility data, where management reported a reduction in the cited failure rate from 25% to 4%; however, the results still require confirmation in U.S. patients. * Pulse believes nsPFA could substantially shorten AFib procedures and reduce ablation applications, while management favors partnering with an established medical-device company to commercialize the technology amid intense competition from existing PFA systems. * MarketBeat previews the top five stocks to own by September 1st. Pulse Biosciences NASDAQ: PLSE is positioning its nanosecond pulsed field ablation technology as a potential next-generation treatment platform for atrial fibrillation and other conditions, President, CEO and Co-Chairman Paul LaViolette said during the Canaccord Genuity 46th Annual Global Growth Conference. LaViolette, who joined the company's board in 2024 before quickly taking the CEO role, said his decision to lead Pulse followed diligence on the company's technology, market opportunity and team. He previously held executive roles at C.R. Bard, Boston Scientific and other medical-technology organizations before becoming a venture capitalist and board member. "I found in it something that I thought was absolutely exceptional," LaViolette said of Pulse's technology and opportunity. Nanosecond PFA technology. Pulse is developing nanosecond pulsed field ablation, or nsPFA, an approach that uses electrical pulses to non-thermally ablate cells through irreversible electroporation. LaViolette contrasted the technology with traditional heat- and cold-based ablation methods, including radiofrequency ablation. According to LaViolette, the company's platform creates biological effects including regulated cell death, in which cells trigger their own demise, while avoiding an inflammatory response. Because the approach is non-thermal, he said it may be used in tight anatomical spaces and near sensitive structures without causing damage. LaViolette said Pulse controls the technology through its development team, know-how and a portfolio of approximately 250 patents. He highlighted Darrin Uecker, David Danitz, the company's chief technology officer and senior vice president of research and development, Chief Medical Officer David Kenigsberg, and Chief Operating Officer Liane Teplitsky as key members of the leadership team. The CEO also cited the involvement of Robert Duggan, whom he described as a major shareholder and investor in the company. LaViolette said Duggan has purchased shares as a public-equity investor and has funded the company's development efforts because of his belief in nsPFA. AFib trial enrollment and prior data. Pulse's primary cardiac opportunity is atrial fibrillation, or AFib, where catheter ablation is used to isolate pulmonary veins and treat abnormal heart rhythms. The company is enrolling its Nano-Pulse AF investigational device exemption, or IDE, study in the United States. LaViolette attributed the trial's enrollment pace to physician interest and results from a European feasibility study involving more than 175 patients, including many followed for more than a year. He said the European study used the same endpoints planned for the IDE trial and generated efficacy results that he characterized as "completely unrivaled." Discover more EV market analysis He said current AFib ablation technologies can deliver approximately a 75% probability of success, while Pulse's European data reduced the cited 25% failure rate to 4%. He cautioned that the results must be replicated in the IDE study and noted that U.S. patients may have different risk factors than the European population. LaViolette also said the technology could shorten procedures and reduce the number of ablation applications needed. He said conventional point-by-point radiofrequency procedures can require 100 to 125 ablations and take more than an hour, while first-generation pulsed field ablation systems have reduced procedures to roughly 45 to 50 minutes and 40 to 50 ablations. Pulse's approach, he said, has the potential to reduce that to 10 ablations and approximately seven to eight minutes from first to last ablation. * Pulse has added fewer than 20 patients to its IDE study. * LaViolette said the change followed an FDA-approved modification to anti-arrhythmic drug failure criteria. * Physicians sought the modification because the original protocol requirements did not reflect changing real-world practice, he said. Competitive landscape and commercial strategy. LaViolette said the AFib ablation market has shifted rapidly toward pulsed field ablation. He cited Boston Scientific's FARAWAVE launch as a major driver of PFA adoption and said Medtronic has gained share following the launch of its Sphere-9 system based on the Affera platform. Those market shifts demonstrate that physicians can switch PFA platforms quickly when new technology is introduced, he said. LaViolette argued that Pulse could be differentiated because it is pursuing nanosecond PFA rather than the microsecond PFA used by current competitors. Despite saying Pulse could feasibly build its own commercial channel, LaViolette said management and the board currently believe a partnership would be the best route to create value, reach physicians and bring the technology to patients. He cited the cost, execution risk and complexity of competing in a market involving mapping systems, ablation tools and related accessories. Additional applications. While AFib is the company's first cardiac indication and requires a Class III device premarket approval application, LaViolette said Pulse already has clearance for general soft-tissue ablation in non-cardiac uses. Its first planned use in that category is treatment of benign thyroid nodules. LaViolette said patients with benign thyroid growths currently may undergo complete thyroid removal, and he believes nsPFA could potentially shift treatment toward a less invasive approach that preserves more tissue. About Pulse Biosciences (NASDAQ:PLSE). Pulse Biosciences, Inc is a clinical-stage bioelectric medicine company that develops and commercializes medical devices based on its proprietary Tissue NanoPoration (TNP) platform. The company's core technology, NanoPulse Stimulation (NPS), delivers ultrashort, high-voltage electric pulses to targeted tissue, triggering cellular responses without the thermal damage associated with traditional energy-based devices. Pulse Biosciences focuses on applications in dermatology and aesthetic medicine, where controlled ablation of unwanted lesions is critical. The company's flagship product, the CellFX(R) System, is designed to treat a range of benign and malignant skin lesions, including seborrheic keratosis, non-melanoma skin cancers, and various epidermal and dermal lesions. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Pulse Biosciences, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Pulse Biosciences wasn't on the list. 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