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Xaira Therapeutics

AI-powered protein design for therapeutics

AI in Residence

Quantitative Biology & BiostatisticsConfirmed live in the last 24 hours
Full-timeSouth San Francisco, CA, USA$10k - $15k /moIn-person

About the Job

Requirements

  • Candidates should have technical depth, intellectual independence, strong research judgment, and evidence of delivering high-quality work through publications, open-source contributions, or production systems.
  • Candidates should demonstrate strong research judgment, including choosing appropriate problems and recognizing what constitutes good evidence.
  • Candidates should demonstrate rigor through careful experimental design, ablations, error analysis, and honest reporting.
  • Candidates should demonstrate systems thinking, including reliability, scalability, and maintainability.
  • Candidates should communicate clearly through writing, documentation, and sharing decisions and assumptions.
  • Candidates should have recent MS or PhD graduation, or equivalent research experience, in machine learning or artificial intelligence, computational biology, biomedical engineering, or related fields.
  • Candidates should demonstrate research excellence through high-quality publications or artifacts; top venues are a plus, while strong preprints, open-source contributions, or shipped systems with demonstrated impact are also considered compelling.
  • Candidates should demonstrate the ability to lead substantial technical work with originality, such as new modeling ideas, rigorous experiments, or production-grade systems adopted by others.
  • Candidates should be motivated to translate rigorous research into reliable, deployable AI systems that support therapeutic discovery.

Responsibilities

  • Develop and advance machine learning models for biological, preclinical, and translational datasets, including multimodal omics, imaging, text, and assay data.
  • Design and implement scalable pipelines for data curation, training, evaluation, and inference integrated into discovery workflows.
  • Own projects end to end, from problem framing and prototyping through validation and deployment.
  • Evaluate robustness and reliability, including generalization, uncertainty, and failure modes, and assess interpretability where it supports scientific decision-making.
  • Propose new technical directions, shape platform capabilities, and raise engineering and research standards through collaboration.
  • Build foundation or representation models over multimodal biological and translational data.
  • Develop methods for small, biased, or noisy datasets, distribution shift, and uncertainty estimation.
  • Build machine learning systems for experimental prioritization, assay interpretation, or translational signal discovery.
  • Develop evaluation frameworks and benchmarks tailored to discovery decision-making.
  • Build tools that make models usable by scientists, including interfaces, automation, and monitoring.
  • Ship one or more models or pipelines used in real discovery workflows.
  • Improve decision quality through better prioritization, faster iteration, or clearer uncertainty.
  • Improve evaluation rigor and reproducibility through strong baselines, error analysis, and reliable metrics.
  • Leave maintainable systems, including tests, documentation, and monitoring, that others can build on.
  • Collaborate with scientific and engineering partners.

Desired Qualifications

  • Top-venue publications, including NeurIPS, ICML, ICLR, CVPR, ACL, Nature Methods, or Cell Systems, are a plus.
  • Strong preprints, open-source contributions, or shipped systems with demonstrated impact are considered compelling alternatives to top-venue publications.
  • The program may support publications and conference presentations when appropriate; publication scope and timing depend on project needs and internal review.

About the Company

Xaira Therapeutics

AI-powered protein design for therapeutics

Xaira Therapeutics uses artificial intelligence to transform drug discovery and development. It builds a pipeline of protein- and antibody-based therapeutics by combining generative AI models from the IPD lab (notably RFdiffusion and RFantibody) with large, multidimensional biological data. The company designs novel proteins and antibodies from scratch to target difficult, previously undruggable biology, then validates and evolves these molecules through iterative data generation that improves its biological foundation models. Unlike many entrants that offer research services, Xaira aims to own and advance its own therapeutic pipeline across multiple modalities, rather than solely providing platforms. The goal is to deliver effective new medicines faster and with a lower chance of failure by integrating AI-driven design, expansive data, and expert leadership.

Company size
201-500
Company stage
Late Stage VC
Total funding
$1B
Headquarters
South San Francisco, CA
Founded
2023

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