Arrowhead Pharmaceuticals

Develops RNAi-based gene-silencing therapies

Tax Manager

Tax AccountingConfirmed live in the last 24 hours

Full-time$130k - $150k

About the Job

Requirements

A bachelor's degree in Accounting, Finance, Tax, Business, or a related field is required.
A CPA and/or master's degree in Business Taxation, Taxation, Accounting, or a related discipline is required.
At least five years of progressive tax experience is required.
Strong working knowledge of ASC 740 and corporate income tax compliance is required.
Experience preparing, reviewing, or managing U.S. federal and state corporate income tax filings, extensions, estimated payments, and related compliance activities is required.
Experience working with third-party tax service providers or external advisors is required.
Working knowledge of indirect taxes, including sales and use tax, value-added tax/goods and services tax, property tax, or similar tax areas is required.
Experience supporting tax audits, tax inquiries, documentation of tax positions, and internal control processes is required.
Advanced proficiency in Microsoft Excel and strong working knowledge of Microsoft Office applications are required.
The role requires the ability to manage multiple priorities, meet deadlines, and work effectively in a collaborative, cross-functional environment.
The role requires demonstrated problem-solving, initiative, and a hands-on, team-oriented approach.
Strong analytical, organizational, written, and verbal communication skills are required.

Responsibilities

Manage and/or review global tax provision and footnote disclosures in accordance with ASC 740.
Manage and review U.S. federal, state, and foreign corporate income taxes prepared by third-party service providers, including returns, extensions, and estimated payments.
Prepare, review, and/or manage indirect taxes, including sales and use tax, value-added tax/goods and services tax, and property taxes.
Manage third-party service providers on projects such as research and development credits, state nexus, sourcing, apportionment, transfer pricing, structuring and planning, international expansion, and Section 382.
Assist with tax audits and other tax-related inquiries.
Document policies, tax positions, and calculations.
Maintain internal controls to comply with SOX regulations.
Partner with Finance, Accounting, Legal, and external service providers to support accurate, timely tax reporting, regulatory compliance, and business initiatives.

Desired Qualifications

Big Four firm experience is preferred.
International tax experience is preferred.
Biotechnology or life science industry experience is preferred.

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Tax Manager will oversee the company’s tax compliance, reporting, and strategic tax planning activities. This role is responsible for managing global tax provision work, corporate income tax filings, indirect tax matters, tax audits, internal controls, and relationships with external tax advisors. The Tax Manager will partner cross-functionally with Finance, Accounting, Legal, and external service providers to ensure accurate and timely tax reporting, compliance with applicable regulations, and effective support of business initiatives.

This position requires strong technical tax knowledge, attention to detail, sound judgment, and the ability to manage multiple priorities in a growing, fast-paced organization. The ideal candidate is hands-on, collaborative, analytical, and comfortable both leading tax-related projects and executing detailed tax work.

This role is based in Pasadena or San Diego, CA with an expectation to be in office 5 days a week.

Responsibilities

Manage, and/or review global tax provision and footnote disclosures in accordance with ASC 740.
Manage and review all aspects of US federal, state and foreign corporate income taxes prepared by third-party service providers. This includes returns, extensions, estimated payments, etc.
Prepare, review and/or manage indirect taxes (e.g. Sales and Use tax, VAT/GST, property taxes, etc.).
Manage third party service providers. Examples of projects are R&D credits, state (nexus, sourcing, apportionment, etc.), transfer pricing, structuring/planning, international expansion, Section 382.
Assist with tax audits and other tax-related inquiries.
Responsible for documenting policies, tax positions, calculations.
Maintain internal controls to comply with SOX regulations.

Requirements

Bachelor’s degree in Accounting, Finance, Tax, Business, or a related field.
CPA and/or Master’s in Business Taxation, Taxation, Accounting, or a related discipline.
5+ years of progressive tax experience.
Strong working knowledge of ASC 740 and corporate income tax compliance.
Experience preparing, reviewing, or managing U.S. federal and state corporate income tax filings, extensions, estimated payments, and related compliance activities.
Experience working with third-party tax service providers or external advisors.
Working knowledge of indirect taxes, including sales and use tax, VAT/GST, property tax, or similar tax areas.
Experience supporting tax audits, tax inquiries, documentation of tax positions, and internal control processes.
Strong analytical, organizational, written, and verbal communication skills.
Advanced proficiency in Microsoft Excel and strong working knowledge of Microsoft Office applications.
Ability to manage multiple priorities, meet deadlines, and work effectively in a collaborative, cross-functional environment.
Demonstrated ability to problem-solve, take initiative, and operate with a hands-on, team-oriented approach.

Preferred

Big 4 firm experience
International tax experience
Biotechnology or life science industry experience

California pay range

$130,000—$150,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

California Applicant Privacy Policy

California pay range 130000 - 150000 USD

About the Company

Arrowhead Pharmaceuticals

Develops RNAi-based gene-silencing therapies

Arrowhead Pharmaceuticals develops medicines using RNA interference (RNAi) to silence disease-causing genes. The company’s approach uses a library of RNA chemistries and delivery methods to trigger RNAi, enabling rapid and durable reduction of target gene expression in cells. This gene-silencing strategy aims to treat severe genetic diseases such as cystic fibrosis and hepatitis B by lowering disease-related proteins. Arrowhead’s products are advanced through discovery and development partnerships, licensing deals, and potential commercialization of approved therapies. The company differentiates itself through a broad RNAi platform, proprietary delivery tech, and collaborations with larger pharma firms to advance its pipeline. Its goal is to provide new treatment options for conditions with limited or no effective therapies by translating gene silencing into medicines that can halt or reverse disease progression.

Company size: 501-1,000
Company stage: IPO
Headquarters: Pasadena, CA
Founded: 2004

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