Arrowhead Pharmaceuticals

Develops RNAi-based gene-silencing therapies

Metrologist 2

Manufacturing Quality & TestPosted on Nov 13

Full-timeVerona, WI, USA$120k - $135k

About the Job

Requirements

A bachelor's degree in a related field and 11 years of relevant experience are required; equivalent job experience is accepted.
Proficiency in reading and understanding engineering drawings is required.
At least five years of experience servicing or overseeing complex laboratory or manufacturing equipment is required.
Knowledge of lockout/tagout (LOTO) is required.
Electrical and mechanical troubleshooting experience is required.
At least five years of experience working in a Good Manufacturing Practice (GMP) setting is required.
Experience creating controlled documentation, such as standard operating procedures and work instructions, is required.
Experience implementing change-control practices for equipment and computer systems is required.
Proficiency in Microsoft Word, Excel, PowerPoint, or similar software is required.
Technical writing skills and attention to detail are required.
Verbal and written communication skills are required.
Adherence to laboratory safety policies and procedures is required.
Ability to collaborate across departments is required.

Responsibilities

Oversee vendor and internal calibration, maintenance, and repair activities, providing support and expertise as needed.
Support regulatory audits by supplying technical expertise.
Perform Blue Mountain Ram Lead reviews on vendor- and internally performed service.
Maintain and develop in-house processes related to equipment calibration and service.
Review and support equipment data trending to inform process improvement and improve service.
Lead and support projects related to improving new or existing development.
Lead activities related to EMS.
Identify process improvements to increase efficiency and reduce equipment downtime.
Create and support equipment change-control documentation.

Desired Qualifications

Pharmaceutical or biotechnology equipment experience is preferred.
Experience working with Blue Mountain Regulatory Asset Management System or an equivalent system is preferred.
Project management experience is preferred.
Leadership experience is preferred.

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Primarily responsible for overseeing the maintenance and requisite qualification for analytical and manufacturing equipment. Also responsible for maintaining and developing new processes in support of calibration, maintenance, and troubleshooting equipment.

This role is full-time onsite, 5 days a week in Verona, WI.

Responsibilities

Oversee vendor and internal calibration, maintenance, and repair activities, providing support and expertise as needed
Support regulatory audits supplying technical expertise
Perform Blue Mountain Ram Lead reviews on vendor and internally performed service
Maintain and develop in-house processes related to the calibration and service of equipment
Review and support equipment data trending to supply process improvement and drive better service
Lead and support projects related to improving new or existing development
Lead activities related to EMS
Identify improvement process to increase efficiency and reduce equipment downtime
Create and support equipment change control documentation

Requirements

Bachelor’s degree in a related field and 11 years of relative experience, equivalent job experience accepted
Must be proficient with reading and understanding engineering drawings
5+ years of experience servicing or overseeing complex laboratory/manufacturing equipment
Knowledge of LOTO (lock out tag out)
Electrical and mechanical troubleshooting experience
5+ years of experience working in a GMP setting
Experience creating controlled documentation (SOP/WI)
Experience implementing change control practices for equipment and computer systems.
Proficient in Microsoft Office Word, Excel, PowerPoint, and similar software
Excellent technical writing skills with high attention to detail
Good verbal and written communication skills
Adhere to laboratory safety policies and procedures
Good collaboration skills with ability to work across departments

Preferred

Pharmaceutical or Biotech equipment experience
Experience working with Blue Mountain Regulatory Asset Management System or equivalent
Project management experience
Leadership experience

Wisconsin pay range

$120,000—$135,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

California Applicant Privacy Policy

Wisconsin pay range 120000 - 135000 USD

About the Company

Arrowhead Pharmaceuticals

Develops RNAi-based gene-silencing therapies

Arrowhead Pharmaceuticals develops medicines using RNA interference (RNAi) to silence disease-causing genes. The company’s approach uses a library of RNA chemistries and delivery methods to trigger RNAi, enabling rapid and durable reduction of target gene expression in cells. This gene-silencing strategy aims to treat severe genetic diseases such as cystic fibrosis and hepatitis B by lowering disease-related proteins. Arrowhead’s products are advanced through discovery and development partnerships, licensing deals, and potential commercialization of approved therapies. The company differentiates itself through a broad RNAi platform, proprietary delivery tech, and collaborations with larger pharma firms to advance its pipeline. Its goal is to provide new treatment options for conditions with limited or no effective therapies by translating gene silencing into medicines that can halt or reverse disease progression.

Company size: 501-1,000
Company stage: IPO
Headquarters: Pasadena, CA
Founded: 2004

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