Associate Director/Principal Scientist @ Generation Bio

Generation Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

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SUMMARY:

Generation Bio is seeking an energetic and highly motivated Associate Director/Principal Scientist to join the Immunology Group. The position will play a key role in development and evaluation of our cell targeted lipid nanoparticle (ctLNP) delivery platform by devising and executing a strategic plan aimed at evaluating ctLNPs interacting with immune cells. The successful candidate will have a depth of experience performing in vitro experiments with primary human immune cells and assay development. The candidate will support the execution and provide direction to scientists conducting vitro PoC and MOA assays using human and/or murine immune cells to further facilitate evaluation of ctLNP and novel target biologies. The ideal candidate will have experience executing in vivo small animal pharmacology studies related to the exploration of immunology in areas of disease related to immunology such as oncology or autoimmunity. The candidate is expected to have a firm grasp of human T cell biology and the design and analysis of complex multicolor flow cytometry endpoints. The candidate will have strong communication skills and be adept at working cross functionally and collaboratively with scientists and stakeholders.

RESPONSIBILITIES:

Conceptualize experimental path to evaluate novel target biology and design PoC in vitro experiments
Contribute to the strategic thinking of novel target concepts
Design and execute in vivo pharmacology studies in WT and disease models
Analyze and report data, synthesizing key results and crafting strategic path forward
CRO management in collaboration with preclinical operations group
Project leadership, responsible for balancing resources and executing on deliverables, with the ability to influence, design, and scope out new project initiatives in a matrixed team
Mentor direct reports and other scientists within the group

QUALIFICATIONS:

PhD in immunology or related field with minimum of 6 years relevant experience required
Experience across multiple fields of immunology, such as deep knowledge of diverse cell types and disease areas required
Track record of contributing to a cross-functional project team and enabling achievement of milestones as a leader and collaborative team player
Deep understanding of flow cytometry and immunophenotyping with complex flow panels
Previous experience designing pharmacology studies required
Curious, detail oriented, eager to tackle hard problems, and ability to communicate complex issues effectively

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Associate Director/Principal Scientist

Immunology Discovery Research

Generation Bio

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