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Regeneron Pharmaceuticals

Develops biopharmaceutical therapies for serious diseases

Executive Director Enterprise Architect

IT OperationsUpdated on Nov 12
Full-time$285.6k - $475.9k /yr

About the Job

Requirements

  • Deep expertise in enterprise architecture frameworks and methodologies such as TOGAF or Zachman, and their practical application in a large, complex organization.
  • Strong technical grounding across cloud platforms (AWS, Azure, and GCP), enterprise integration, data architecture, and application architecture patterns.
  • Strong grounding in enterprise integration architecture, including API management, event-driven patterns, and integration platform strategy.
  • Working knowledge of AI/ML platforms, data and analytics architecture, and emerging technology evaluation.
  • Experience with enterprise security architecture, identity and access management, and industry-relevant regulatory and compliance frameworks such as GxP and data privacy.
  • Familiarity with modern software delivery practices, including DevOps, CI/CD, microservices, and infrastructure-as-code.
  • Proven ability to build, scale, and lead high-performing architecture teams, including hiring, developing, and retaining technical talent.
  • Experience leading architecture functions within a global, matrixed organization, including geographically distributed teams.
  • Ability to mentor and grow architects and technical leaders, building bench strength and succession depth.
  • Experience establishing and sustaining a collaborative operating model with peer architecture functions, including clear accountability without duplicated ownership.
  • Strong business acumen and ability to translate business strategy into an executable technology roadmap.
  • Sound judgment in balancing innovation, risk, cost, and speed to market in architecture decision-making.
  • Ability to lead through ambiguity and structure clear technology direction from complex or evolving business requirements.
  • Executive presence and ability to influence and communicate effectively with senior business and technology leaders, including at EVP and possibly board level.
  • Ability to translate complex technical topics into clear, business-relevant narratives for non-technical audiences.
  • Bachelor’s degree in Computer Science, Information Technology, Engineering, or a related field.
  • 17+ years of progressive experience in enterprise architecture, IT strategy, or technology leadership roles.
  • 10+ years in senior leadership roles guiding architecture, engineering, or technology strategy teams within a large, complex, global organization.

Responsibilities

  • Define and own enterprise architecture strategy, principles, and target-state blueprints across data, cloud and infrastructure, application, and integration domains, incorporating security and AI architecture standards in partnership with the CISO and CAIO organizations.
  • Translate business strategy and digital transformation priorities into a coherent, multi-year enterprise technology roadmap.
  • Establish and evolve the enterprise architecture operating model so architecture decisions scale with business growth and complexity.
  • Assess emerging technology trends, including AI/ML, cloud-native platforms, and automation, and determine strategic fit and adoption paths.
  • Champion a business-capability-first architecture approach that maps technology investments to business outcomes.
  • Establish and lead enterprise architecture governance, including review boards, design authority processes, and exception management.
  • Define and enforce enterprise architecture standards, patterns, and reference architectures across build, buy, and integration decisions.
  • Own architecture reviews for major programs and capital investments, ensuring alignment with enterprise standards, security, and regulatory requirements.
  • Maintain the enterprise architecture repository of current- and future-state models, technology inventories, and roadmaps as an authoritative source of truth.
  • Partner with Security, Risk, and Compliance to ensure architecture decisions meet enterprise risk tolerance and regulatory obligations, including GxP and data privacy.
  • Lead enterprise-wide technology rationalization to identify opportunities to consolidate, retire, or modernize legacy platforms.
  • Partner with Finance and business unit leaders to build business cases for architecture-driven investments, balancing innovation and cost discipline.
  • Guide platform and vendor selection for enterprise-critical systems, evaluating architectural fit, scalability, and total cost of ownership.
  • Own cloud and infrastructure strategy to support performance, resilience, and cost efficiency at scale.
  • Drive integration architecture strategy to enable seamless data flow and interoperability among core business systems.
  • Advise business unit leaders on translating business problems into technology-enabled solutions.
  • Partner with product, engineering, and program leaders to embed architecture early in delivery and reduce rework and technical debt.
  • Lead architecture input into major digital transformation and modernization initiatives, ensuring solutions support scale, security, and long-term maintainability.
  • Evaluate and guide adoption of AI, automation, and data platforms to accelerate business capabilities and differentiation.
  • Resolve cross-functional architecture conflicts through data-driven, business-aligned decisions.
  • Provide senior oversight and quality assurance for solution architectures developed by domain and solution architects.
  • Ensure architectural consistency and reuse across programs, preventing siloed or duplicative technology investments.
  • Guide design of resilient, secure, and scalable platform architectures for enterprise applications, data platforms, and integration layers.
  • Champion architecture practices supporting DevOps, CI/CD, and infrastructure-as-code adoption across delivery teams.
  • Oversee technical due diligence for mergers, acquisitions, and strategic partnerships, assessing architectural risk and integration complexity.
  • Present enterprise architecture strategy, roadmaps, and investment recommendations to executive leadership and technology governance forums as needed.
  • Build trusted relationships with Digital and Technology Leadership and business unit executives so architecture remains a strategic partner.
  • Communicate technical concepts and trade-offs in clear, business-relevant terms to non-technical executive audiences.
  • Represent the enterprise architecture function in vendor, industry, and partner forums and stay current on best practices and market direction.
  • Establish and sustain collaboration with the CISO and CAIO organizations’ architecture teams, defining decision rights, escalation paths, and shared standards to align security and AI architecture without duplicated ownership.
  • Partner with the business strategy function that owns business architecture to keep enterprise technology roadmaps traceable to its business capability models.
  • Build, lead, and develop the architecture team, directly leading the Data & AI, Cloud & Infrastructure, Application, and Integration Domain Architects.
  • Mentor and coach architects and senior technical leaders, supporting career growth, technical depth, and succession planning.
  • Establish architecture communities of practice and knowledge-sharing forums to elevate architecture maturity across the technology organization.
  • Champion diversity, equity, and inclusion in hiring, development, and team culture within the architecture function.
  • Model and reinforce intellectual curiosity, pragmatism, and accountability across the architecture team.

Desired Qualifications

  • A Master’s degree or MBA is strongly preferred.

About the Company

Regeneron Pharmaceuticals

Develops biopharmaceutical therapies for serious diseases

Regeneron Pharmaceuticals develops and commercializes medicines for serious diseases, with a focus on cancer, eye diseases, allergic and inflammatory diseases, and infectious diseases. Its products come from using proprietary research capabilities and technologies to discover and develop therapies, often in collaboration with academic, research, and industry partners. Revenue comes from selling approved medicines and from licensing its technologies and entering co-development and co-commercialization partnerships. The company works with healthcare providers and regulators to ensure treatment delivery and safety. Its goal is to improve patient outcomes by bringing life-transforming medicines to market through rigorous R&D and strategic collaborations, maintaining leadership in biopharmaceutical innovation.

Company size
10,001+
Company stage
IPO
Headquarters
Town of Mount Pleasant, New York
Founded
1988

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