We engineer stem cell transplants that shield healthy cells from targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.
Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.
What we value in our fellow Voracians
Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is seeking a Manufacturing Specialist I/II who is an enthusiastic and driven individual for cGMP manufacturing for early phase cell therapy manufacturing facility. The candidate will be responsible for providing support and executing in the manufacturing of Vor’s gene-edited cell therapies and maintaining compliance of cGMPs in manufacturing areas.
Key areas of responsibility:
- Supports/performs cleanroom operations, including reviewing and tracking of equipment records for PM/calibration, cleanroom cleaning and maintenance
- Work with Quality and MSAT groups to support the transfer and execution of manufacturing processes in the internal manufacturing site
- Strict adherence to current good manufacturing practices, standard operating procedures, and manufacturing documentation
- Establish and follow written procedures for clear and accurate documentation of equipment operation, process instructions and process data
- Contributes to on-going continuous improvement projects
- Other duties and projects as needed to support departmental needs
Skills and requirements:
- BS or MS in Biology, Biochemistry, Engineering, or related field
- 1 - 5 years of experience in cGMP manufacturing with hands-on experience in cell therapy production and aseptic manufacturing technique preferred
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you’ll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
