Staff Scientist ADPE

Salary Range: 181084 to 188327 (Currency: USD) (Pay period: per-year-salary)

Responsibilities:

• Implement expression/purification/conjugation processes to generate protein reagents at milligram to gram level scales.
• Manage, coordinate, and run developability assessment requests.
• Collaborate extensively across functions and contribute to prioritization and planning within group and project teams to meet company goals.
• Accurately and clearly document experimental notes, protocols, and results.
• Present results at project team and departmental meetings.
• Support development of novel technologies, including high-throughput capabilities, for protein production, analytical, and characterizations.
• Prepare to learn and grow in a highly productive, fun and collaborative environment! 

We’d love to hear from you if:

• Your academic background includes a PhD in protein biochemistry with 5+ years, MS with 10+ years of therapeutic protein production experience.
• You have proven hands-on expertise in various protein characterization methods and tools including SDS-PAGE, WB, LAL, CE-SDS, Analytical SEC and RP-HPLC, SEC-MALS, DLS, DSF and mass spectrometry.
• You are an expert in protein purification using affinity, IEX, HIC and mixed-mode chromatography.
• You are capable of designing protein purification strategies and trouble-shooting problems independently.
• You have experience with generating difficult-to-produce, low-expressing intracellular, membrane and/or secreted fusion proteins. To enable antibody discovery and protein engineering.
• Your expertise in high throughput purification technologies is a plus.
• Your expertise in various site-specific ASO or SiRNA bio-conjugation techniques and DAR determination is a plus.
• Your familiarity with standard text, graphic, and presentation software is required and database/data archival software systems is helpful.
• You have excellent interpersonal, communication and presentation skills with the ability to mentor junior scientists as well as positively influence project direction and strategy.
• You take pride in being self-motivated and a creative problem solver.
• You have a point of view but are low ego.