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Ohr

Cell-free biomanufacturing for critical chemicals

Director of Synthetic Chemistry

Process EngineeringConfirmed live in the last 24 hours
Full-timeLafayette, CO, USA

About the Job

Requirements

  • A PhD in organic, process, or materials chemistry with 12 or more years beyond it, or equivalent depth reached another way.
  • At least 3 years managing chemists against external delivery dates, including hiring and leveling a team from a standing start.
  • Personal ownership of a synthetic route that reached pilot scale.
  • Real depth in at least one of energetics chemistry or metal extraction chemistry.
  • Process safety leadership, including reaction calorimetry, exotherm and quench design, HAZOP participation, and treating hazard as an input to route choice.
  • Route selection on cost per kilogram, with a specific decision that can be explained end to end.
  • The ability to manage ITAR- and export-controlled information and run a team within that regime.
  • Writing and presentation skills sufficient for government program reviews.
  • Eligibility to serve as an employee possessor of explosive materials under federal law; candidates must not be a prohibited person as defined under 18 U.S.C. § 842(i).

Responsibilities

  • Own route selection across all three verticals based on delivered cost per kilogram and hazard, and set standards for proposing, costing, assessing, and documenting routes.
  • Lead the synthetic chemistry team.
  • Carry the energetics program from a 1 kg characterized sample in early 2027 to a validated 10 kg/day pilot in 2029, including designing experiments that set the pilot design basis and overseeing the subsequent review, HAZOP, and commissioning sequence.
  • Sequence campaigns competing for the same bench, decide what slips when demand exceeds capacity, and defend those decisions to product lines.
  • Lead process safety, including running calorimetry programs before conditions are fixed, designing quenching for exothermic workups, managing the handling case for a Category 1B carcinogen, and addressing siting and insurance before laboratory work begins.
  • Maintain a candidate pipeline to support product lines when a kill test returns a negative result.
  • Make build-or-buy decisions on intermediates and defend the cost model to the board and a government customer.
  • Establish the Colorado laboratory, including equipment specification, long-lead procurement, licensing scope for energetic materials, and compliance for export control and procurement-controlled reagents.
  • Represent chemistry at government program reviews, with partner laboratories and contract development and manufacturing organizations, and to customers reviewing technical data packages.
  • Hire the two senior technical anchors and establish the hiring bar for the function.
  • Create and maintain a campaign sequence across three verticals.
  • Establish route, hazard, and cost review as a standing process.
  • Hire and develop the FY27 team and plan for the FY28 hiring wave.

Desired Qualifications

  • Experience delivering government-funded, milestone-based development programs.
  • Experience establishing a laboratory from scratch, including equipment specification, licensing, long-lead procurement, and first-year operating discipline.
  • Experience converting exothermic or corrosive batch chemistry to flow or continuous processes.
  • Experience with insensitive high explosives, working in an ATF-licensed facility, or DoW explosive safety standards.
  • Experience with hydrometallurgical reagents, chelating ligands, or solvent extraction chemistry.
  • Experience with condensation polymer chemistry where product specification is a molecular weight distribution.
  • An active security clearance or the ability to obtain one.

About the Company

Ohr

Cell-free biomanufacturing for critical chemicals

OHR designs and manufactures critical chemicals using Creationary Chemistry, starting from simple, abundant feedstocks rather than crude oil, with modular, local production. It combines engineered enzymes with primordial chemistry in a cell-free system to build carbon chains with high selectivity, creating privileged intermediates that become end products without living cells or toxic waste. This approach eliminates traditional extraction, separation, and refining steps and uses a single platform to access energetics, propellants, binders, and advanced materials across defense, mining, and propulsion. The goal is industrial sovereignty and independence, enabling distributed production near local feedstocks under a build-own-operate model to bypass concentrated supply chains.

Company size
11-50
Company stage
Not listed
Total funding
Not listed
Headquarters
San Diego, CA
Founded
2024

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