GENERAL ROLE DESCRIPTION:

The Senior Scientist role will be within the Biomarkers & Immunology group, part of the Development Sciences department. During AAV therapeutics development, the group performs immunogenicity assessments, biomarker measurements, molecular assays, and exploratory clinical research. Our responsibilities include in-depth data analysis, interpretation, and bioanalytical method development. Methods are then rigorously validated at CROs to characterize their performance and ensure that high-quality data are generated. Working closely with multiple cross-functional stakeholders, such as Clinical Sciences, Pharmtox, Clinical Operations, Technology Innovation, and Project Management, our data deliverables and analyses significantly impact key program decisions.

This role will report to a Principal Scientist in the Biomarkers & Immunology group and be part of a talented, motivated, and creative team of scientists who are critical for the success of 4DMT’s mission to develop a deep portfolio of targeted genetic medicines. While on-site presence is required to perform laboratory work, a flexible hybrid work schedule can be accommodated when analyzing data and remotely managing partner organizations.

RESPONSIBILITIES:

• Developing and designing cutting-edge, innovative bioanalytical assays for preclinical and clinical use in multiple therapeutic areas, e.g., ophthalmology, pulmonology, CNS, etc., through individual hands-on expertise and scientific teamwork
• General areas of assay development will be in ligand-binding assays, cell-based assays, and molecular assays to evaluate immunogenicity, PK, biodistribution, and biomarkers
• Contributing to the operational implementation of assays in non-clinical and clinical studies, including IND-enabling studies
• Designing & executing experiments, analyzing and presenting data to line management and study teams
• Assessing the utility and selection of contract research organizations (CROs), managing technology transfer, overseeing assay method development, qualification and validation
• Effectively mentoring junior-level staff and acting as a resource for scientific expertise
• Maintaining current awareness of scientific literature and actively applying new concepts and technologies
• Supporting research initiatives such as new technology development and platform improvement projects
• Writing and reviewing technical documents, study protocols and reports, manuscripts, and presenting results at scientific meetings
• Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices
• Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.

QUALIFICATIONS:

Education & Experience:

• Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field
  • With a PhD – 8+ years of industry experience, Master’s degree with 10+ years, Bachelors with 12+ years
• Bioanalytical method development, immunogenicity monitoring, and/or biomarker assay development
• Scientific acumen as demonstrated by co-authored publications in peer-reviewed scientific journals and ability to work in a matrixed environment
• Prior experience selecting and efficiently managing CROs
• AAV gene therapy

Skills:

• Successfully demonstrated ability to work independently in designing, developing, and executing new assay methods
• Competence in use of MesoScale Discovery platform instruments and other plate-based platforms; protein labeling, detection, and purification techniques
• Experience with tissue culture of primary cells and established cell lines
• Experience with PCR and multicolor flow cytometry
• Ability to multi-task and support more than one project simultaneously
• Highly organized and motivated; strong analytical, organizational, and problem-solving skills
• Strong work ethic, flexibility, and cooperative can-do attitude
• Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches
• Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one-on-one discussions, team meetings, and external partnership interactions
• Understanding and knowledge of key scientific software programs (including standard microplate readers with SoftMax software, Microsoft Office, JMP or Prism, Adobe Photoshop).

Base salary compensation range: $160,000 - $180,000

Please note the base salary compensation range and actual salary offered to the final candidate depends on various factors: the candidate’s geographical location, relevant work experience, skills, and years of experience.