Full-Time

Senior Scientist

Biomarkers & Immunology

Posted on 9/24/2024

4D Molecular Therapeutics

4D Molecular Therapeutics

201-500 employees

Develops gene therapies for genetic diseases

Biotechnology
Healthcare

Compensation Overview

$160k - $180kAnnually

Senior

Oakland, CA, USA

On-site presence required for laboratory work; flexible hybrid work schedule available for data analysis and remote management.

Category
Lab & Research
Interdisciplinary Research
Life Sciences
Required Skills
Communications
Adobe Photoshop
Requirements
  • Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field
  • With a PhD – 8+ years of industry experience, Master’s degree with 10+ years, Bachelors with 12+ years
  • Bioanalytical method development, immunogenicity monitoring, and/or biomarker assay development
  • Scientific acumen as demonstrated by co-authored publications in peer-reviewed scientific journals and ability to work in a matrixed environment
  • Prior experience selecting and efficiently managing CROs
  • AAV gene therapy
  • Successfully demonstrated ability to work independently in designing, developing, and executing new assay methods
  • Competence in use of MesoScale Discovery platform instruments and other plate-based platforms; protein labeling, detection, and purification techniques
  • Experience with tissue culture of primary cells and established cell lines
  • Experience with PCR and multicolor flow cytometry
  • Ability to multi-task and support more than one project simultaneously
  • Highly organized and motivated; strong analytical, organizational, and problem-solving skills
  • Strong work ethic, flexibility, and cooperative can-do attitude
  • Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches
  • Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one-on-one discussions, team meetings, and external partnership interactions
  • Understanding and knowledge of key scientific software programs (including standard microplate readers with SoftMax software, Microsoft Office, JMP or Prism, Adobe Photoshop)
Responsibilities
  • Developing and designing cutting-edge, innovative bioanalytical assays for preclinical and clinical use in multiple therapeutic areas, e.g., ophthalmology, pulmonology, CNS, etc., through individual hands-on expertise and scientific teamwork
  • General areas of assay development will be in ligand-binding assays, cell-based assays, and molecular assays to evaluate immunogenicity, PK, biodistribution, and biomarkers
  • Contributing to the operational implementation of assays in non-clinical and clinical studies, including IND-enabling studies
  • Designing & executing experiments, analyzing and presenting data to line management and study teams
  • Assessing the utility and selection of contract research organizations (CROs), managing technology transfer, overseeing assay method development, qualification and validation
  • Effectively mentoring junior-level staff and acting as a resource for scientific expertise
  • Maintaining current awareness of scientific literature and actively applying new concepts and technologies
  • Supporting research initiatives such as new technology development and platform improvement projects
  • Writing and reviewing technical documents, study protocols and reports, manuscripts, and presenting results at scientific meetings
  • Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices
  • Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.
4D Molecular Therapeutics

4D Molecular Therapeutics

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4D Molecular Therapeutics develops gene therapies aimed at treating serious genetic diseases by delivering specific genetic material to patients' cells. The company utilizes a unique technology called Therapeutic Vector Evolution to create adeno-associated virus (AAV) vectors, which act as delivery vehicles for therapeutic genes targeting specific cells in the body. Unlike many competitors, 4DMT focuses on precision medicine for genetic disorders, including cystic fibrosis, and operates in a specialized biopharmaceutical market. Their goal is to conduct thorough research and clinical trials to ensure the safety and effectiveness of their therapies, ultimately commercializing them through direct sales or partnerships with larger pharmaceutical companies.

Company Stage

IPO

Total Funding

$170.2M

Headquarters

Emeryville, California

Founded

2013

Growth & Insights
Headcount

6 month growth

18%

1 year growth

42%

2 year growth

77%
Simplify Jobs

Simplify's Take

What believers are saying

  • 4DMT secured $75 million in Series C financing for growth and development.
  • Positive interim data from Phase 1/2 AEROW trial for 4D-710 in cystic fibrosis.
  • Astellas Pharma partnership could yield up to $962 million in future milestones.

What critics are saying

  • Potential competition from CRISPR Therapeutics and Editas Medicine in gene therapy.
  • High cost and complexity of clinical trials may cause financial strain.
  • Regulatory challenges, like FDA's clinical hold on 4D-310, can delay treatments.

What makes 4D Molecular Therapeutics unique

  • 4DMT uses proprietary Therapeutic Vector Evolution for advanced AAV vector creation.
  • The company focuses on aerosolized genetic medicines for diseases like cystic fibrosis.
  • 4DMT's R100 vector efficiently transduces the entire retina for eye disease treatments.

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