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Full-Time

Senior Scientist

Biomarkers & Immunology

Confirmed live in the last 24 hours

4D Molecular Therapeutics

4D Molecular Therapeutics

51-200 employees

Develops gene therapies for genetic diseases

Biotechnology
Healthcare

Compensation Overview

$160k - $180kAnnually

Senior, Expert

Oakland, CA, USA

On-site presence required for laboratory work; flexible hybrid work schedule available for data analysis and remote management.

Category
Lab & Research
Interdisciplinary Research
Life Sciences
Required Skills
Communications
Adobe Photoshop
Requirements
  • Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field
  • With a PhD – 8+ years of industry experience, Master’s degree with 10+ years, Bachelors with 12+ years
  • Bioanalytical method development, immunogenicity monitoring, and/or biomarker assay development
  • Scientific acumen as demonstrated by co-authored publications in peer-reviewed scientific journals and ability to work in a matrixed environment
  • Prior experience selecting and efficiently managing CROs
  • AAV gene therapy
  • Successfully demonstrated ability to work independently in designing, developing, and executing new assay methods
  • Competence in use of MesoScale Discovery platform instruments and other plate-based platforms; protein labeling, detection, and purification techniques
  • Experience with tissue culture of primary cells and established cell lines
  • Experience with PCR and multicolor flow cytometry
  • Ability to multi-task and support more than one project simultaneously
  • Highly organized and motivated; strong analytical, organizational, and problem-solving skills
  • Strong work ethic, flexibility, and cooperative can-do attitude
  • Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches
  • Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one-on-one discussions, team meetings, and external partnership interactions
  • Understanding and knowledge of key scientific software programs (including standard microplate readers with SoftMax software, Microsoft Office, JMP or Prism, Adobe Photoshop).
Responsibilities
  • Developing and designing cutting-edge, innovative bioanalytical assays for preclinical and clinical use in multiple therapeutic areas, e.g., ophthalmology, pulmonology, CNS, etc., through individual hands-on expertise and scientific teamwork
  • General areas of assay development will be in ligand-binding assays, cell-based assays, and molecular assays to evaluate immunogenicity, PK, biodistribution, and biomarkers
  • Contributing to the operational implementation of assays in non-clinical and clinical studies, including IND-enabling studies
  • Designing & executing experiments, analyzing and presenting data to line management and study teams
  • Assessing the utility and selection of contract research organizations (CROs), managing technology transfer, overseeing assay method development, qualification and validation
  • Effectively mentoring junior-level staff and acting as a resource for scientific expertise
  • Maintaining current awareness of scientific literature and actively applying new concepts and technologies
  • Supporting research initiatives such as new technology development and platform improvement projects
  • Writing and reviewing technical documents, study protocols and reports, manuscripts, and presenting results at scientific meetings
  • Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices
  • Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.
4D Molecular Therapeutics

4D Molecular Therapeutics

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4D Molecular Therapeutics develops gene therapies aimed at treating serious genetic diseases by delivering specific genetic material to patients' cells. The company utilizes a unique technology called Therapeutic Vector Evolution to create adeno-associated virus (AAV) vectors, which act as delivery vehicles for therapeutic genes targeting affected cells. Unlike many competitors, 4DMT focuses on precision medicine for genetic disorders, including cystic fibrosis, and emphasizes rigorous research and clinical trials to ensure the safety and effectiveness of its therapies. The company's goal is to commercialize these gene therapies through direct sales or partnerships with larger pharmaceutical firms, while also securing funding to support its development efforts.

Company Stage

IPO

Total Funding

$595M

Headquarters

Emeryville, California

Founded

2013

Growth & Insights
Headcount

6 month growth

21%

1 year growth

31%

2 year growth

56%
Simplify Jobs

Simplify's Take

What believers are saying

  • Successful clinical trials, such as the positive interim data from the Phase 1/2 AEROW trial, bolster confidence in 4DMT's therapeutic pipeline.
  • The recent $75 million Series C financing provides substantial capital to advance R&D and clinical programs.
  • The appointment of experienced executives, like Uneek Mehra as Chief Financial and Business Officer, strengthens the company's leadership team.

What critics are saying

  • The biopharmaceutical market is highly competitive, with numerous companies vying to develop similar gene therapies.
  • Regulatory hurdles and clinical trial setbacks, such as the initial clinical hold on 4D-310, can delay product development and commercialization.

What makes 4D Molecular Therapeutics unique

  • 4DMT leverages its proprietary 'Therapeutic Vector Evolution' technology to create advanced AAV vectors, setting it apart from competitors in the gene therapy space.
  • The company's focus on aerosolized genetic medicines, such as 4D-710 for cystic fibrosis, highlights its innovative approach to gene delivery.
  • Strategic partnerships, like the $962M deal with Astellas Pharma, underscore 4DMT's ability to attract significant investment and collaboration opportunities.