The Company:
FL85 is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. FL85’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
"Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies."
Position Summary:
The Research Associate/Senior Research Associate will be a member of the mRNA Technologies Group at FL85, supporting laboratory research to develop the next generation of information molecule therapeutics. The successful candidate will have an understanding of principles necessary for establishing high-yield, high-quality and scalable mRNA production processes. A background in mRNA process optimization and nucleic acid characterization techniques is required along with a strong understanding of molecular biology and general lab operations. The Research Associate/Senior Research Associate will assist the mRNA Technologies Group with assays and data analysis, using these experimental results to help coordinate with other working groups at FL85.
Key Responsibilities:
- Laboratory-based, hands-on contribution to mRNA generation to facilitate in vitro and in vivo preclinical studies.
- Contribute to development and optimization of new technologies and methods related to improved mRNA synthesis and purification.
- Help implement larger scale mRNA production processes including single-use bioreactors
- Characterization and quantitation of mRNA and other nucleic acids (impurity assessment, cell-based potency, immunogenicity assays, NGS and/or Sanger sequencing analysis, etc.).
- Analysis and documentation of results in an electronic lab notebook or other technical reporting format.
- Sharing and interpreting experimental results with other working groups to coordinate effort toward project goals.
Basic Qualifications:
- B.S. or M.S. in Biology, Biochemistry, Molecular Biology, or related field with at least two years of relevant experience
- Experience with mRNA synthesis, purification, and characterization including familiarity with chromatography, tangential flow filtration, fragment analyzer, dot blot assay, etc.
- Strong molecular biology experimental skills, including experience executing protocols, troubleshooting, and carrying out literature searches for technology evaluation and selection
- Proven ability to work independently and cross-functionally with highly skilled teams in a fast-paced, entrepreneurial, and technical environment
- Strong organizational and problem-solving skills
- Motivated, curious, and comfortable working with highly technical projects and personnel
- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
- Comfortable with challenging technical problems and deadlines
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
