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AstraZeneca

Global pharmaceutical company developing prescription medicines

Associate Scientist

Bioprocess & BiomanufacturingUpdated on Nov 9
Full-timeGaithersburg, MD, USAIn-person

About the Job

Requirements

  • A Bachelor of Science degree with at least 2 years of experience, or a Master of Science degree with 0 or more years of experience, in the biopharmaceutical industry or an academic laboratory.
  • Hands-on experience with mammalian cell culture and aseptic processing.
  • Experience and knowledge of cell therapy drug product development, especially cell product formulation, filling, freezing, storage, thawing, and post-thaw handling.
  • Experience with basic cell-based analytical methods such as automated cell counting and viability assessment.
  • Ability to organize and analyze experimental data, prepare clear summaries, draw scientifically sound conclusions, and communicate results to project teams.
  • Time-management skills and ability to manage multiple priorities in a dynamic, interdisciplinary environment.
  • Effective written and verbal communication skills and ability to collaborate with colleagues across functions.

Responsibilities

  • Support CAR-T cell product development and optimization in early-stage development by designing, developing, and executing experiments in formulation, fill/finish, and cryopreservation processes.
  • Execute laboratory experiments following protocols and troubleshoot routine technical issues.
  • Operate relevant cell-processing, fill/finish, controlled-rate freezing, cryogenic storage, and thawing equipment.
  • Perform assays to assess CAR-T product quality and cellular health, including cell count, viability, recovery, apoptosis, flow-cytometric phenotype, and functional readouts.
  • Collect, organize, analyze, and interpret experimental data and communicate conclusions.
  • Maintain accurate and timely documentation in laboratory notebooks and electronic systems, and author or contribute to protocols, technical reports, and presentations.
  • Collaborate with analytical development, process development, and external partners to support robust and scalable CAR-T drug product processes.
  • Follow established safety, biosafety, aseptic, and data-integrity practices and contribute to a safe, organized, and inspection-ready laboratory environment.

Desired Qualifications

  • Experience with advanced analytical methods such as flow cytometry, apoptosis measurements, or functional assays.
  • Experience with closed or automated cell-processing platforms such as Finia, Sepax, Cue, LOVO, or other cell-processing systems.
  • Knowledge of cryobiology, formulation science, and excipient screening.
  • Experience with Design of Experiments (DoE) and statistical data analysis.

About the Company

AstraZeneca

Global pharmaceutical company developing prescription medicines

AstraZeneca develops and markets prescription medicines and vaccines worldwide, with a focus on oncology, cardiovascular/metabolic, respiratory, and infectious diseases. Its products work by targeting specific biological pathways or cells, using small-molecule therapies, biologics, and vaccines to treat diseases or prevent infections. It differentiates itself through its dual heritage from Sweden and the UK, a broad pipeline, and strong R&D and collaborations that move from discovery to patient access. Its goal is to improve people’s health by discovering, developing, and delivering medicines and vaccines to patients worldwide.

Company size
10,001+
Company stage
IPO
Headquarters
Cambridge, United Kingdom
Founded
1913

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