Research Associate 2
A-Alpha Bio
Research Associate 2
A-Alpha Bio
Biologics discovery via high-throughput affinity screening
A-Alpha Bio is an early-stage, rapidlygrowing biotechnology platform companyheadquartered in Seattle, WA.We are focused on building the foundational data layer for AI-driven protein engineering.Weprovide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models.In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.
This role is not open to remote applicants and would require relocation to Seattle, WA.
Starting Salary Range: $75,000 - $88,000 annually
Exemption Status: Exempt
Location Expectations: Onsite
Reporting To: Manager II, Technical Operations
Role Description
A-Alpha Bio is seeking a Research Associate II to support our Technical Operations team’s execution of our AlphaSeq assay. In this role, you’ll execute DNA and yeast library construction, matings, next-generation sequencing, cell sorting, and flow cytometry to support interrogation of protein-protein interactions. Ideal candidates will have strong organizational skills, impeccable attention to detail, and an interest in executing screening assays at scale.
Key Responsibilities
Qualifications & Experience
Required
Preferred
In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.
A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!
Biologics discovery via high-throughput affinity screening
A-Alpha Bio helps drug developers accelerate discovery of biologics, which are therapeutic proteins. Its platform rapidly and quantitatively measures millions of protein–protein binding affinities, enabling simultaneous characterization of how a library of proteins binds to many targets. This allows screening antagonists across full interaction networks and identifying biologics with specificity to multiple targets. Revenue comes from service contracts, licenses, and collaborative partnerships with pharmaceutical and biotech firms. The company differentiates itself by providing a scalable, quantitative binding-measurement platform that can profile binding across large target networks, supporting fast, targeted discovery. Its goal is to advance drug discovery by delivering high-precision binding data to enable the design of specific, effective biologics.
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