NewLimit

Develops epigenetic medicines to extend healthspan

Senior/Research Associate - Single Cell Technology

Translational Research & Bench BiologyConfirmed live in the last 24 hours

Full-timeSouth San Francisco, CA, USA$75k - $100kIn-person

About the Job

Requirements

A bachelor's degree in cell biology, molecular biology, or a related natural science, or equivalent industry experience.
At least 2 years of work experience in a cell or molecular biology laboratory in an academic or industry setting.
Experience with standard molecular biology workflows, including nucleic acid extraction, quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, next-generation sequencing library construction, library quantification, and quality control.
Experience with necropsy, organ and tissue collection, primary tissue dissociation, mammalian cell culture, and sample processing, including single-cell suspension preparation, nuclei isolation, and fixation.

Responsibilities

Measure the biodistribution, pharmacokinetics, and efficacy of reprogramming medicines using traditional molecular assays and genomics methods.
Design and execute experiments involving the isolation, culture, and processing of cells, tissues, and organs for molecular profiling.
Collaborate with the Epigenetic Editing team to perform large-scale single-cell perturbation experiments with custom chemistries.
Perform single-cell profiling experiments to map epigenetic features of age-related disease and evaluate interventions.

Desired Qualifications

Experience with in vivo animal handling.
Experience with single-cell genomics methods, such as 10x Genomics, Parse Bio, Perturb-seq, CROProp-seq, or similar methods.
Experience troubleshooting or optimizing next-generation sequencing workflows.
Experience with flow cytometry sorting for single-cell preparations.

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking a Senior/Research Associate with experience in biological sample processing and molecular biology to join our Single Cell Technology and Assay Development group. Our team develops and applies advanced molecular and bioanalytical technologies to support therapeutic discovery and development, spanning single-cell genomics, biomarker development, biodistribution, and bioanalytical method development.
As a member of our team, you will:

Measure the biodistribution, pharmacokinetics & efficacy of reprogramming medicines using traditional molecular assays as well as frontier genomics methods
Design and execute experiments involving the isolation, culture, and processing of cells, tissues, and organs for molecular profiling
Collaborate with our Epigenetic Editing team to perform large-scale, single cell perturbation experiments with custom chemistries
Perform state-of-the-art single cell profiling experiments to map epigenetic features of age-related disease and evaluate interventions

Requirements

Bachelor’s degree in cell biology, molecular biology, or a related natural science or industry experience
2+ years of work experience in a cell or molecular biology laboratory (academic or industry)
Experience with standard molecular biology workflows (e.g., nucleic acid extraction, qPCR, ELISA, NGS library construction, library quantification and QC)
Experience with necropsy, organ/tissue collection, primary tissue dissociation, mammalian cell culture and sample processing (e.g. single cell suspension preparation, nuclei isolation, fixation)

Nice to have

Experience with in vivo animal handling
Experience with single cell genomics methods (such as 10x Genomics, Parse Bio, Perturb-seq/CROProp-seq or similar)
Experience troubleshooting or optimizing NGS workflows.
Experience with flow cytometry sorting for single-cell preparations.

Benefits

Health, dental, and vision insurance
401(k) with company match
Industry-leading paid time off (PTO) -- 20 days/year for all employees + holidays
Paid parental leave
Meals and snacks on-site

Salary Range: $75,000 to $100,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

About the Company

NewLimit

Develops epigenetic medicines to extend healthspan

NewLimit develops medicines that aim to extend healthy years by reprogramming the epigenome of aging cells. It works by identifying aging-related epigenetic changes using single-cell genomics, machine learning, and high-throughput functional assays, then creating interventions to reverse those changes in targeted tissues such as the immune system and liver. Compared with others, NewLimit combines a specific focus on epigenetic reprogramming with a data-driven, tissue-targeted pipeline and pursues partnerships with pharma and biotech players to develop its proprietary medicines. Its goal is to deliver a new class of medicines that significantly increases the healthspan for patients with age-related diseases.

Company size: 51-200
Company stage: Series C
Total funding: $650M
Headquarters: South San Francisco, CA
Founded: 2022

Recently Posted Jobs

Explore more opportunities at NewLimit

See more jobs