Senior/Executive Director - Translational Systems Immunology

Salary Range: 268500 to 316000 (Currency: USD) (Pay period: per-year-salary)

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

Translational and Systems Immunology Strategy

• Lead immunology-focused nonclinical and clinical translational strategy for ARM programs, ensuring analyses address program-critical biological and clinical questions.

• Define immune-monitoring strategies designed to deepen understanding of mechanism of action, pharmacodynamic effects, clinical activity, durability, resistance, safety, and differentiated phenotypes.

• Translate emerging science in T-cell engagers, CAR-T, autoimmune disease, immune reset, and immunotherapy into focused hypotheses and analytical plans for Janux programs.

• Lead the identification and prioritization of key non-clinical and clinical questions that can distinguish ARM biology and performance from contemporary immunotherapy approaches (e.g. TCEs, CAR-T), and collaboratively drive integrated evidence-generation strategies across translational, non-clinical, and clinical functions to establish platform differentiation.

Integrated Data Analysis and Interpretation

• Lead and perform integrated analyses of scRNA-seq, CITE-seq, TCR-seq, high-dimensional flow cytometry, phosphoflow, cytokine, proteomic, and/or spatial datasets.

• Personally, mine datasets and direct analyses performed by bioinformatics partners to identify immunological signatures, response patterns, and mechanistic insights.

• Integrate nonclinical, translational, and clinical evidence into clear conclusions and recommendations for program teams and leadership.

• Compare Janux datasets with relevant published and competitor datasets to identify differentiated mechanisms and translational opportunities.

• Investigate mechanisms associated with efficacy, durability, resistance, cytokine release syndrome, immune exhaustion, B-cell depletion, and immune reconstitution.

Team and Cross-Functional Leadership

• Lead, mentor, and develop laboratory scientists and computational collaborators generating and analyzing immunology data.

• Partner with Research, Translational Medicine, Bioinformatics, Biomarkers, Clinical Development, Clinical Operations, Regulatory, and program leadership to align sample strategy, assays, analyses, and decision timelines.

• Communicate complex immunology findings through clear visualizations, scientific narratives, and decision-oriented presentations.

• Guide external collaborators, consultants, and CROs as needed, ensuring quality, scientific rigor, and timely delivery.

• Contribute to regulatory documents, scientific communications, and external presentations, as appropriate.

• Other duties as deemed necessary.

REQUIRED EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS, AND ABILITIES

• Ph.D., M.D., or equivalent advanced degree in Immunology, Systems Biology, Computational Biology, or a related scientific discipline.

• Extensive biotechnology or pharmaceutical experience in translational immunology, systems immunology, immune monitoring, or a closely related field, with level determined by scope and leadership experience.

• Deep expertise in T-cell and B-cell biology, including activation, exhaustion, memory, depletion, reconstitution, and immune-mediated disease biology.

• Demonstrated ability to integrate complex high-dimensional datasets across non-clinical and clinical studies and translate findings into program decisions.

• Hands-on proficiency with multiple immunology data types, including single-cell sequencing and high-dimensional flow cytometry; ability to independently interrogate data is required.

• Experience leading multidisciplinary scientific teams and influencing in a matrixed drug-development environment.

• Excellent scientific judgment, communication, and presentation skills, including the ability to explain complex data to varied audiences.

• Ability to thrive in a fast-paced, evolving biotechnology environment and balance strategic leadership with hands-on scientific contribution.

PREFERRED EXPERIENCE, SKILLS, AND ABILITIES

• Experience with T-cell engagers, CAR-T or other cell therapies, bispecific biologics, autoimmune disease, hematologic malignancies, or immune-reset approaches.

• Experience with CITE-seq, TCR-seq, phosphoflow, proteomics, spatial profiling, and integrated multi-omics analysis.

• Experience designing clinical immune-monitoring strategies and supporting early clinical development.

• Working knowledge of bioinformatics workflows and experience managing bioinformaticians or external computational partners.

• Publication or presentation record demonstrating scientific leadership in translational or systems immunology.