Director Bioprocess Development - Biologics Research

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we’re in. Are you?

About the Role:

We’re looking for a Director, Bioprocess Development on the Biologics Research team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Director, Biologics Research, you’ll lead the design, buildout, and execution of upstream and downstream capabilities within our Biologics Research organization.

What You'll Do:

In this role, you’ll have the opportunity to <play a critical role in establishing a high-performing team and state-of-the-art laboratories to support a diverse pipeline of biotherapeutic programs from early discovery through preclinical CMC. You’ll also:

Team Leadership & Organizational Build

• Build, lead, and mentor a high-performing research bioprocess development team
• Establish a collaborative, accountable, and scientifically rigorous team culture
• Set priorities and allocate resources across multiple concurrent programs

Laboratory & Capability Development

• Design and oversee the buildout of new state-of-the-art research bioprocess development laboratories
• Define equipment strategy and select platforms for upstream processing (USP): microbial and mammalian expression systems, as well as downstream processing (DSP): purification workflows including chromatography and filtration
• Implement scalable, fit-for-purpose technologies aligned with early-stage and preclinical needs

Technical Leadership (Upstream & Downstream)

• Provide subject matter expertise in recombinant protein expression in bacterial and mammalian systems, cell culture process development, media optimization, scale-up strategies, and protein purification processes including flocculation, tangential flow and depth filtration, buffer exchange, and affinity, ion exchange, and mixed mode chromatography
• Drive development of robust, reproducible processes suitable for preclinical material generation
• Establish platform approaches and best practices for rapid program advancement

Hands-On Execution

• Contribute directly to experimental design, experimentation, troubleshooting, and data interpretation
• Lead or support critical experiments, especially during early lab setup and high-priority programs
• Develop and review protocols, reports, and technical documentation

Program Support & Cross-Functional Collaboration

• Partner closely with Discovery, Analytical, Technical Operations, and Preclinical Development teams
• Support multiple biologics programs across modalities (e.g., enzymes, antibodies, fusion proteins)
• Ensure alignment of bioprocess strategies with program timelines and CMC expectations
• Provide input into candidate selection based on developability and manufacturability

CMC & Preclinical Development Interface

• Establish processes and documentation to support transition into formal CMC development
• Collaborate with external partners or internal CMC teams for tech transfer and scale-up

Ensure early processes are designed with downstream manufacturability in mind

Who You Are:

You have a PhD in chemical engineering, biochemical engineering, biology, or related field with 5+ years of industry experience, or M.S. with 8+ years of industry experience. You are or you also have:

• Demonstrated experience in biologics process development within biotech or pharmaceutical settings.
• Deep experience in both upstream and downstream bioprocess development.
• Expertise in early- to late-stage preclinical CMC for biotherapeutic development candidates.
• Hands-on experience with microbial expression systems (specific expertise with E. coli), mammalian expression systems, optimization of bioreactor operations (bench-scale; scale-up knowledge preferred), optimization of protein purification and characterization workflows (with knowledge of scalable processes), and construction and optimization of commercial expression strains (both microbial and mammalian)
• Successful track record of tech transfer to technical operations groups and/or CDMOs.
• A builder’s mindset with the ability to create structure while maintaining agility and willingness to be hands-on while operating at a strategic level.
• Passion for developing people and advancing innovative biologics programs.
• Proven track record of building and leading teams and/or functional groups.
• Strong leadership and mentoring skills
• Experience managing multiple programs in a fast-paced, research-driven environment
• Excellent communication and cross-functional collaboration abilities

Nice to have (but not required):

• Experience building laboratories and selecting capital equipment
• Exposure to early GMP considerations
• Familiarity with a range of biologic modalities (e.g., enzymes, mAbs, bispecifics, engineered proteins, half-life extension technologies)

Where You’ll Work

This role is based out of our Lebanon, NH office and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs.

Travel Requirements

Minimal travel expected

#LI-BA

#LI-ONSITE

Pay Range:

$185,000.00-252,500.00 Annual

Life at Insmed
 

At Insmed, you’ll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)

• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration

• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance

• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities

• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan. 

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. For more information, please refer to our Equal Employment Opportunity and Non-Discrimination Statement on our Careers site.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application   or interview process, please contact us by email at [email protected]  and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.