Manager – Commercial Executive Operations

The Opportunity: 

Revolution Medicines is establishing its European headquarters and expanding its presence across Spain and Portugal. The Manager Commercial Execution Ops role leads the execution of high-complexity, cross-functional initiatives that ensure operational readiness, governance, and alignment across the European region. Serving as an operational support to the VP, General Manager Spain and Portugal, this individual drives the design and implementation of scalable frameworks that enhance business integration and cross-regional collaboration. The ideal candidate thrives in a dynamic, fast-paced environment, demonstrates strong business acumen, and can build trusted partnerships across leadership teams and global functions. 

Key responsibilities include: 

• Assist Spain and Portugal leadership team, cross-functional stakeholders and leaders to execute complex, cross functional initiatives across Spain and Portugal operations. 

• Support and maintain integrated governance frameworks and ensure strategic alignment with country, global and regional priorities. 

• Support and follow up of leadership team meetings.

• Lead organization of monthly Spain and Portugal Leadership Team meetings and Spain and Portugal governance meetings, including agenda setting, minute taking, follow up tracking and logistics. 

• Work in close collaboration with other project coordinators and operational team members in European Commercialization to ensure a connected and engaged team. 

• Plan and execute international travel itineraries including flights, ground transport, visas, accommodations, and contingency planning. Ensure seamless transitions between engagements and proactive resolution of travel disruptions. 

• Ensure operational excellence, budget tracking, transparent reporting and documentation integrity. 

• Lead coordination of internal contract management and purchasing across functions and affiliates, ensuring alignment with Legal, Compliance and Finance governance. 

• Support and coordinate office setup activities across Spain and Portugal and affiliate sites under Finance, Legal, and HR governance. 

• Lead office management and general administrative duties, draft internal communications in working closely with Corporate Communications and assist with onboarding of new employees in liaison with HR and EHS. 

• Drive ad hoc tasks of various sizes and complexity. 

• Build trusted relationships across the organization and externally facilitate effective collaboration. 

• Handle confidential matters with utmost discretion and professionalism. 

Required Skills, Experience and Education: 

• Bachelor’s degree in business administration, Life Sciences, or related field. 

• 8+ years' experience with progressive responsibilities leading highly-complex, cross-functional programs within the biopharma or life sciences industry. 

• Experience in project management, business operations, or chief-of-staff roles. 

• Project management certification required or in progress. 

• Proven ability to influence governance and deliver strategic business outcomes across global operations. 

• Exceptional organizational skills and ability to manage multiple priorities with precision and speed. 

• Strong event management and stakeholder engagement capabilities. 

• Strong interpersonal and communication skills with the ability to work effectively across functions and cultures. 

• Demonstrated understanding of governance structures and compliance principles in a regulated industry. 

• Fluent in English; additional European languages are an asset. 

• Must be based in Madrid.

Preferred Skills: 

• Experience supporting senior executives or leadership teams in a regional or global matrix organization.  

• Familiarity with European affiliate operations, business systems, and internal policy frameworks. 

• Advanced proficiency in Microsoft Office Suite and project management tools (e.g., Smartsheet, Asana). 

• Proactive, solution-oriented mindset and ability to thrive in a start-up or scale-up environment. 

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