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Substrate Bio

Autonomous AI-driven wet labs for biological experimentation

Member of Technical Staff - ML Infrastructure

Applied Machine LearningConfirmed live in the last 24 hours
Full-timeNo salary listedIn-person

About the Job

Requirements

  • Experience building infrastructure for large language model inference or reinforcement learning training.
  • Systems fundamentals and the ability to profile slow or failing workloads to identify their causes.
  • Hands-on experience with GPU clusters, distributed training, model serving, or high-throughput inference, including scheduling, utilization, and cost.
  • Experience with Docker, Kubernetes, Ray, or Terraform, and long-running jobs with retries, checkpointing, and clear failure reporting.
  • Good judgment on technical trade-offs, including when a prototype is sufficient and when a system needs to be hardened, simplified, or rebuilt.
  • Ability to clearly communicate and write about system design, operational risk, and engineering trade-offs.
  • Fluency in Python and daily use of coding agents.

Responsibilities

  • Build infrastructure for post-training and reinforcement learning, enabling model post-training, benchmarking, and agent building and training.
  • Build and maintain systems for training and post-training runs, inference serving for open and closed models, running agents through reinforcement-learning environments, evaluation harnesses, and data pipelines.
  • Create clear interfaces for researchers and AI agents to launch, monitor, and debug runs.
  • Own the stack end to end, from design and implementation through deployment, documentation, and maintenance.
  • Set engineering standards for testing, observability, and versioning.
  • Find and remove bottlenecks across training, rollout generation, evaluation runs, data movement, and GPU utilization.
  • Ensure training runs and evaluations are reproducible on each new version of the data and comparable with earlier runs.
  • Improve the stack’s performance, scalability, and reliability as the team and its workloads grow.
  • Work closely with reinforcement-learning, evaluation, and biological machine-learning researchers and engineers, and the software team responsible for capturing experimental data.

Desired Qualifications

  • Experience with inference engines such as SGLang or vLLM and reinforcement-learning training frameworks such as veRL, Miles, or TRL.
  • Experience with agent environment and evaluation frameworks such as Harbor.
  • Experience with sandboxed agent execution such as Firecracker or gVisor.
  • Experience with compilers, custom kernels, or optimization for specific GPU hardware.
  • Experience with data versioning and lineage for machine-learning datasets.
  • Experience building infrastructure for biological or other scientific data.

About the Company

Substrate Bio

Autonomous AI-driven wet labs for biological experimentation

Substrate Bio operates AI-native data-production infrastructure for biology, connecting computational models with real-world experimentation. The company runs a network of autonomous, robotics-powered wet labs, starting in London with a second planned for San Francisco, running standardized experiments with full provenance, metadata, and quality control. Researchers access the labs via API, submitting experiment parameters and receiving structured data and metadata, while foundation models help design assay selections, cell systems, and gene panels. What sets Substrate Bio apart is its closed feedback loop, where better data improves its models and better models design better experiments. The goal is to make biological experimentation as programmable and scalable as computation itself.

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