Postdoctoral Research Fellow - Chromatin Regulator and Immune Interaction in Blood Cancers

Job Details

The laboratory of Dr. Jianping Li (jianpinglilab.com) at the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Thomas Jefferson University (TJU) is seeking a highly motivated postdoctoral fellow to join our team on NIH/NCI-funded projects. Dr. Li’s lab focuses on the roles of chromatin regulators and immune interaction in blood cancers, especially in the initiation of acute lymphoblastic leukemia and lymphoma, relapse, chemotherapy resistance, and CNS infiltration. We explore mutant chromatin regulators-driven phenotype and molecular mechanisms using cell lines, conditional mouse models, patient-derived xenografts (PDXs), and cutting-edge technologies such as CUT&RUN, ChIP-Seq, single-cell RNA-Seq, ATAC-Seq, Hi-C, proteomics, drug screening, flow cytometry and sorting, and CRISPR editing and screening (Nature Communications 2017, Cancer Discovery 2022, and Nature Chemical Biology 2024).

Job Description

Eligibility Requirements: We are looking for highly motivated and enthusiastic postdoctoral fellows with a recent PhD or PhD/MD in molecular biology, T-cell immunology, cancer biology, or related fields. The candidate should have a strong interest in one of the following basic and translational research areas: chromatin regulation, cancer epigenetics, stem cell biology, immune interactions, CNS infiltration, and the development of targeted therapy. We expect you to join our energetic group, enjoy the joy of research, and receive excellent training and career development to become an independent scientist. Experience in molecular cloning, CRISPR editing and screening, multi-omics sequencing analysis, flow cytometry, and sorting will be preferred. Qualified candidates should send their curriculum vitae and contact information of three professional references to Dr. Jianping Li ([email protected]).

Institute: Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Jefferson is recognized as high performing in cancer care by U.S. News & World Report and is designated a Comprehensive Cancer Center by the National Cancer Institute (NCI) for excellence in cancer care, prevention, and research. The NCI-designated SKCCC at TJU is home to national thought leaders across multiple cancer research disciplines and multi-institutional collaborations, announcing the expansion and deepening of hematologic malignancy research with the Blood Cancer Center of Excellence (BCCE). Our faculty lead paradigm-shifting research into the initiation and progression of cancer, as well as resistance mechanisms and potential therapeutic targets. Here, researchers collaborate across multiple departments and specialties to address some of the most complex challenges in healthcare.

Work Shift

Workday Day (United States of America)

Worker Sub Type

Regular

Employee Entity

Thomas Jefferson University

Primary Location Address

951 Locust Street, Philadelphia, Pennsylvania, United States of America

Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University, home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200+ undergraduate and graduate programs to more than 8,300 students. Jefferson Health, nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas, serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years.    

Jefferson is committed to providing equal educa­tional and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status. 

Benefits

Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including medical (including prescription), supplemental insurance, dental, vision, life and AD&D insurance, short- and long-term disability, flexible spending accounts, retirement plans, tuition assistance, as well as voluntary benefits, which provide colleagues with access to group rates on insurance and discounts. Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service. All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps), have access to medical (including prescription) insurance.

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