Director – LNP Discovery

Job Description:

Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California.

Position Summary

CRISPR Therapeutics is seeking an individual with deep expertise in the RNA delivery space to lead our mRNA delivery efforts. Reporting to the Head of Translational Biology, they will oversee the development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery. The successful candidate must be able to work in a fast paced and highly dynamic Biotech environment. The ideal candidate will be a leader and a great team player with excellent communication skills and an effective, inspiring management style.

Responsibilities

• Oversee the development of novel LNPs (e.g., lipid chemistry, composition, formulation process)
• Oversee the development of cell‑based assays and animal models for LNP testing.
• Lead LNP Delivery biology efforts, including protein design and bioconjugation to ensure successful LNP optimization
• Collaborate  cross-functionally with pharmacology and programming teams to achieve key milestones
• Drive the company’s RNA extrahepatic delivery strategy, with a particular emphasis on IP and key deliverables
• Stay up to date on RNA delivery literature and prepare technical reports and white papers
• Prepare technical documents and manuscripts for IP filings and publications
• Present scientific findings internally and externally at key scientific conferences and industry events

Minimum Qualifications

• PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field
• 10+ years of experience with lipid nanoparticles, siRNA, and protein design
• Demonstrated experience successfully translating animal models from mouse to non-human primate
• Excellent communication skills (oral and written)
• Track record of innovation in LNP research, spanning bioconjugation, protein design and/or binder design
• Strict record keeping skills (eLN)
• Proven team leader with a track record of  strong  research team leadership
• Ability to synthesize various inputs and make recommendations on strategic approaches we can take as a company in the area of LNP research
• Ability to operate effectively in both detail and high-level settings and strength in navigating
• Ability to think strategically and influence others, and approach challenges with a proactive, ownership mindset

Preferred Qualifications

• Biotech Industry experience
• Knowledge of the drug development process

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

​Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.  

Director, LNP Discovery: Base pay range of $195,000 to $215,000+ bonus, equity and benefits

The range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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