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Janux Therapeutics

Clinical-stage biotech developing tumor-activated immunotherapies

Vice President / Senior Vice President - Clinical Development

Biology & BiotechConfirmed live in the last 24 hours
Full-timeSan Diego, CA, USA

About the Job

Requirements

  • MD or DO with subspecialty in immunology, autoimmune diseases, or related fields.
  • Demonstrated success as a senior clinical leader, such as a therapeutic area head or franchise lead, in large pharma or biotech, with broad immunology experience.
  • Proven track record of strategic leadership in clinical development, portfolio management, and cross-functional team building.
  • Experience driving change and building new capabilities.
  • Deep understanding of early drug development, clinical trial processes, and regulatory requirements in immunology/inflammation.
  • Strong ability to critically evaluate data, literature, and presentations.

Responsibilities

  • Set and execute the strategic vision for clinical development in autoimmune diseases, ensuring alignment with corporate goals and maximizing portfolio value.
  • Lead cross-functional teams in the design and implementation of clinical development strategies, focusing on innovation, differentiation, and speed to market.
  • Oversee clinical program execution at a strategic level, delegating operational and hands-on responsibilities to clinical teams and direct reports.
  • Maintain ultimate accountability for medical monitoring, ensuring patient safety and clinical integrity, while delegating day-to-day monitoring activities to appropriate team members.
  • Provide expert guidance and strategic input on clinical trial design, regulatory strategy, and data interpretation.
  • Serve as the primary medical and scientific spokesperson for the immunology franchise, internally and externally.
  • Cultivate relationships with key opinion leaders, investigators, and external partners to advance the immunology pipeline.
  • Drive organizational growth, talent development, and succession planning within the clinical development function.

About the Company

Janux Therapeutics

Clinical-stage biotech developing tumor-activated immunotherapies

Janux Therapeutics develops cancer immunotherapies that activate the immune system inside tumors to attack cancer while sparing healthy tissue. Its products are tumor-activated and use a proprietary platform masking technology to reduce toxic side effects and improve efficacy compared with traditional T cell engagers. The company advances drug candidates through clinical trials, aiming for regulatory approval and eventual commercialization, with revenue expected from partnerships, licensing, and the sale of approved therapies. Its lead program JANX007 is being evaluated in a Phase 1 trial (ENGAGER PSMA 01) for metastatic prostate cancer to assess safety and preliminary effectiveness.

Company size
51-200
Company stage
IPO
Headquarters
San Diego, CA
Founded
2017

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