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Substrate Bio

Autonomous AI-driven wet labs for biological experimentation

Member of Technical Staff - Applied RL

Natural Language Processing & LLMsPosted on Nov 5
Full-timeNo salary listed

About the Job

Requirements

  • Hands-on experience training large language models with reinforcement learning methods such as PPO or GRPO, including reward design and detecting reward hacking.
  • Hands-on experience with reinforcement-learning training frameworks such as veRL, Miles, or TRL; reinforcement-learning environment frameworks such as Harbor or Prime Intellect's verifiers; and inference engines such as vLLM or SGLang.
  • Experience building agent harnesses and long-horizon tasks with tool use, such as search, code execution, and external APIs.
  • Experience designing learning signals for long trajectories, including verifiers, large language model judges, process reward models, and credit assignment across steps.
  • Ability to conduct rigorous comparisons with matched compute, repeated runs, noise estimates, ablations, and held-out problems.
  • Ability to clearly communicate experiment design, results, and their limitations in writing.
  • Strong Python and PyTorch skills, and daily use of coding agents.

Responsibilities

  • Own how the agents learn, including building the harnesses and reinforcement-learning environments they work in and post-training the models that run through them.
  • Build agents that address long-horizon scientific problems by reading papers, querying databases, running code, calling biological models, deciding what to test next, and detecting when experiments have gone wrong.
  • Build environments where agents carry out experimental work, not only plan it.
  • Design rewards carefully for scientific settings where feedback is noisy, expensive, and slow to arrive.
  • Determine whether agent improvements came from the model itself or changes to the harness, tools, or task.
  • Work closely with Bio ML researchers, evaluation and infrastructure engineers, software engineers, and scientists.

Desired Qualifications

  • Experience applying reinforcement learning or agents to biological problems, for example with frameworks such as ProtRL.
  • Experience with multi-agent setups, such as proposer and critic agents or debate.
  • Experience learning from noisy or delayed rewards and calibrating model confidence.
  • Publications, open-source work, or public benchmarks in reinforcement learning, agents, or post-training.

About the Company

Substrate Bio

Autonomous AI-driven wet labs for biological experimentation

Substrate Bio operates AI-native data-production infrastructure for biology, connecting computational models with real-world experimentation. The company runs a network of autonomous, robotics-powered wet labs, starting in London with a second planned for San Francisco, running standardized experiments with full provenance, metadata, and quality control. Researchers access the labs via API, submitting experiment parameters and receiving structured data and metadata, while foundation models help design assay selections, cell systems, and gene panels. What sets Substrate Bio apart is its closed feedback loop, where better data improves its models and better models design better experiments. The goal is to make biological experimentation as programmable and scalable as computation itself.

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