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Rapport Therapeutics

Develops precision neuromedicines for brain disorders

Director – Clinical Business Operations

Business OperationsConfirmed live in the last 24 hours
Full-timeBoston, MA, USA$230k - $255k /yr

About the Job

Requirements

  • A Bachelor's degree in Life Sciences, Business, Finance, or a related field is required.
  • At least 12 years of experience in biotechnology, pharmaceutical, or clinical research organizations with progressive responsibility in Clinical Operations, business operations, finance, or vendor management is required.
  • Demonstrated experience managing clinical budgets, forecasting, accruals, and financial reporting is required.
  • A strong understanding of clinical vendor contracting, statement of work development, and contract negotiations is required.
  • Experience supporting portfolio governance, resource planning, and operational reporting within Clinical Development or Clinical Operations is required.
  • The ability to partner effectively with Finance, Legal, Procurement, and Clinical Operations stakeholders is required.
  • Strong analytical, organizational, and problem-solving skills with attention to detail are required.
  • Excellent communication and leadership skills with the ability to influence across functions and levels are required.

Responsibilities

  • Lead the business operations function for Clinical Operations, providing strategic oversight of budgets, forecasting, contracts, vendor management, resource planning, and portfolio governance.
  • Develop, manage, and monitor Clinical Operations budgets and forecasts, ensuring accurate financial planning, accruals, spend tracking, and reporting across the clinical portfolio.
  • Oversee the review, negotiation, execution, and management of vendor contracts, statements of work, change orders, and consulting agreements in partnership with Legal, Procurement, Finance, and Clinical Operations.
  • Establish and maintain portfolio-level reporting, operational dashboards, metrics, and governance processes to support decision-making and provide visibility into program performance, resource utilization, and financial health.
  • Partner with Clinical Operations leadership to evaluate business risks, operational priorities, and resource needs, driving proactive solutions to support portfolio objectives.
  • Lead vendor governance activities, monitor performance and budget adherence, and identify opportunities to improve quality, efficiency, and cost-effectiveness across external partnerships.
  • Develop and implement scalable business processes, tools, and operating models that enhance operational excellence, consistency, and compliance across Clinical Operations.
  • Support annual operating plans, long-range forecasting, and strategic planning initiatives by providing financial and operational insights to senior leadership.
  • Ensure operational and financial activities are conducted in accordance with company policies, regulatory requirements, and inspection-readiness expectations.
  • Serve as a trusted business partner across Clinical Operations, Finance, Legal, Procurement, and Clinical Development, fostering cross-functional collaboration and continuous improvement.

Desired Qualifications

  • An advanced degree is preferred.

About the Company

Rapport Therapeutics

Develops precision neuromedicines for brain disorders

Rapport Therapeutics develops precision neuromedicines for neurological disorders. The company focuses on discovering and developing drugs that act only in disease-relevant areas of the brain to reduce symptoms with fewer side effects. Their discovery platform uses region-specific RAPs (Receptor Associated Proteins) to guide drug targeting to specific brain cells or regions, aiming to improve patient benefit. Unlike many peers, Rapport emphasizes selective targeting through RAPs and relies on experienced leadership to drive science and partnerships, with revenue from developing and potentially running clinical trials and related services. The goal is to provide treatments for drug-resistant epilepsies and mood disorders by delivering therapies that are active only where needed in the brain, reducing unwanted effects and improving outcomes.

Company size
51-200
Company stage
IPO
Headquarters
Boston, MA
Founded
2022

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