Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it’s an exciting time to be part of Team Olema.

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity.

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer’s darolutamide in metastatic castration-resistant prostate cancer by the end of this year.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day.

If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.

About the Role >>> Director, Data Science

As the Director of Commercial Data Science reporting to the SVP of Commercial Strategy and Operations, you will who will play a pivotal role in Olema’s commercialization efforts by enabling strategic decision-making, utilizing advanced data analytics and machine learning techniques to optimize commercial performance. This individual will work cross-functionally to develop the roadmap and strategic application of data science (inclusive of predictive analytics, AI and machine learning). This individual will be responsible for turning complex datasets into actionable insights that enhance the company’s go to market strategies, omnichannel efforts, improve market access, and drive revenue growth.

This role combines the application of data science with a strong understanding of the biotech industry, commercialization, market dynamics, and physician behavior. The ideal candidate is comfortable working with large, multifaceted datasets, leveraging statistical models, and communicating findings clearly and compellingly to non-technical stakeholders.

This role is based out of either our San Francisco or Boston office and will require approximately 20% travel.

Your work will primarily encompass:

Cross-Functional Collaboration & Strategic Leadership

Work with a diverse set of stakeholders, including Insights & Analytics, Marketing, Market Access, Medical Affairs, and Sales teams to understand business objectives to develop the roadmap and strategic application of data science
Provide data-driven insights and strategic recommendations to support commercialization efforts

Data Analysis & Reporting

Develop and maintain advanced analytical models to support commercial decision-making to inform Olema’s go-to market strategies, identify opportunities to enhance and elevate physician and patient experiences, improve market access, and drive revenue growth
Analyze and interpret large datasets (e.g., claims, sales, CRM, marketing) to uncover insights and provide actionable recommendations to cross-functional teams
Design and execute experimentations and customer behavior analysis to assess the effectiveness of commercial strategies and identify opportunities to refine commercial approach

Predictive Modeling, Machine Learning & AI

Apply machine learning and statistical modeling techniques to predict trends, physician behavior, market dynamics, and sales performance
Build and refine predictive models to assist in local sales planning, market opportunity identification, and resource allocation
Utilize advanced algorithms to optimize field teams’ effectiveness and identify high-value customers or market segments
Identify opportunities to leverage AI to automate work

Visualization & Communication

Create and present clear, compelling visualizations and reports to senior leadership, translating complex data analyses into actionable insights and business strategies
Provide regular updates and strategic recommendations based on data trends and performance metrics
Develop and implement automated reporting solutions to enhance the efficiency of operations
Work with IT to ensure data pipelines, tools, and dashboards are efficient, scalable, and aligned with commercial needs

Ideal Candidate Profile >>>

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role.

Knowledge

Bachelor's degree in Marketing, Business, Life Sciences, or related field required. Advanced degree preferred
10+ years of relevant work experience, including 8+ years in data science or advanced analytics, with a focus on commercial applications in the biotechnology or pharmaceutical industry

Experience

Strong understanding of biotech or pharmaceutical market dynamics, patient access, healthcare system intricacies, and regulatory requirements
Ability to develop and implement strategic marketing initiatives, with a data-driven approach and strong analytical skills
Excellent verbal and written communication skills, with the ability to convey complex information clearly and empathetically to patients and healthcare providers
Proven ability to work effectively across functions and lead collaborative initiatives with internal and external stakeholders
Exceptional organizational skills with experience managing multiple projects, timelines, and priorities in a fast-paced environment

Attributes

Strategic synthesizer: Connects disparate information and identifies the insights that matter most to a business decision
Structured problem solver: Frames ambiguous questions into clear hypotheses, workstreams, and decision pathways and brings a consulting-style rigor to problem solving
Collaborative: Works effectively across disciplines and develops strong partnerships across Commercial, Market Access, Medical Affairs, Finance, and other functions
Comfortable with ambiguity: Thrives in a fast-moving environment where information is incomplete and priorities evolve
High integrity: Brings rigor, objectivity, sound judgment, and appropriate challenge to strategic decision-making

The base pay range for this position is expected to be $220,000 - $240,00 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.

#LI-MK1

Important Information >>>

We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.

Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.

Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.

Olema Oncology

Director – Commercial Data Science

About the Job

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About the Company

Olema Oncology

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