Investigative Safety Scientist/Toxicologist

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.
 

Job Summary(Primary function) 

We are seeking a highly motivated Investigative Safety Scientist/Toxicologist to develop and apply innovative approaches to identify, characterize, and mitigate safety risks associated with small molecules and emerging modalities. The successful candidate will combine strong expertise in mechanistic toxicology with advanced in vitro models and data-driven approaches to elucidate mechanisms of toxicity, improve translation to humans, and inform portfolio decisions.

Working collaboratively across Research and Development, this scientist will build on existing investigative and predictive strategies to develop fit-for-purpose safety approaches that support candidate selection and progression, address new and existing safety concerns throughout product life cycle, and contribute to strategic leadership in investigative safety.

Essential Functions of the Job(Key responsibilities)

• Develop and execute investigative toxicology strategies to elucidate mechanisms of toxicity and address potential safety liabilities.
• Design and apply fit-for-purpose in vitro and ex vivo models and new approach methodologies (NAMs), including advanced 2D and 3D cultures, organoids, co-cultures, and organ-on-a-chip systems. 
• Evaluate and implement emerging technologies, automation, and high-throughput approaches to improve toxicity prediction and translational safety assessment. Collaborate with internal and external partners to drive technological innovation.
• Design and oversee in vivo investigative studies and integrate mechanistic, computational, and multi-omics data to identify safety liabilities, biomarkers, and translational relationships.
• Collaborate with nonclinical safety scientists and cross-functional teams to translate scientific findings into actionable safety strategies and portfolio decisions. Advise on appropriate model selection, risk characterization, and follow-up strategies, and provide recommendations to inform candidate progression.
• Provide support and strategic leadership for the safe development of diverse modalities across multiple organ systems.
• As needed, serve as a discovery-facing project toxicologist, providing nonclinical safety strategies to support drug discovery and candidate progression through candidate nomination. Regulatory-phase project toxicology responsibilities may be considered based on the candidate’s experience and preferences.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Ph.D. in Toxicology, Pharmacology, Cell Biology, or a related discipline, with 6–10 years of relevant biotechnology or pharmaceutical experience.
• Strong expertise in investigative and mechanistic toxicology and in approaches to characterize drug-induced safety liabilities.
• Experience with advanced in vitro models and assay development, including 3D cultures, organoids, co-cultures, organ-on-a-chip systems, and relevant cellular and molecular techniques.
• Familiarity with omics and computational approaches applied to mechanistic toxicology.
• Demonstrated success working within cross-functional drug discovery and development teams.
• Proven agility to permit work across different modalities and organ systems.
• Strong scientific judgment, critical thinking, and problem-solving skills, with the ability to translate complex findings into actionable recommendations.
• Excellent communication, collaboration, and organizational skills.

Disclaimer:  The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications.  Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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