Janux Therapeutics

Clinical-stage biotech developing tumor-activated immunotherapies

Senior Director - Clinical Supply Chain

Clinical Research OperationsConfirmed live in the last 24 hours

Full-time

About the Job

Requirements

A bachelor's degree in life sciences, supply chain, or a related field is required.
At least 12 years of experience in biotech or pharmaceutical supply chain, including at least 4 years of people management experience within a clinical supply chain organization.
Strong experience supporting Phase 2 and Phase 3 clinical trials.
Experience supporting global clinical trials, including EU, APAC, and Canada, and multi-region labeling and distribution requirements.
Biologics experience is required.
Ability to operate hands-on within a small to mid-size biotech environment.
Expertise in clinical supply planning, forecasting, and inventory management.
Experience managing external vendors, including contract development and manufacturing organizations, depots, and logistics providers.
Working knowledge of interactive response technology systems and clinical supply infrastructure.
Understanding of Good Clinical Practice guidelines, 21 CFR, and Annex 13 requirements.
Ability to operate effectively in a fast-paced, evolving environment and navigate ambiguity.
Problem-solving skills focused on practical execution.
United States work authorization is required.

Responsibilities

Lead and develop clinical supply strategies across Phase 1–3 programs.
Ensure uninterrupted investigational medicinal product supply across global, multi-region clinical trials.
Lead end-to-end clinical supply operations, including packaging, labeling, distribution, returns, reconciliation, and destruction.
Provide strategy and support for global logistics, including import/export activities and depot strategy, while ensuring compliance with country-specific labeling and regulatory requirements.
Provide strategic leadership, cross-functional alignment, and operational oversight to ensure successful execution of key activities across Clinical Operations, Quality, Regulatory, and CMC functions.
Contribute to and review clinical trial documentation, including clinical protocols, pharmacy manuals, batch records, drug labels, and shipping documentation; oversee interactive response technology strategy, setup, and execution.
Partner with CMC to align manufacturing schedules with clinical supply needs and scale-up activities, and oversee comparator sourcing and supply strategies as needed.
Select, manage, and oversee external vendors, including contract development and manufacturing organizations, depots, packaging providers, and logistics providers; manage requests for proposals, statements of work, and vendor performance.
Partner with Quality Assurance on vendor qualification, audits, compliance activities, and development and maintenance of supply chain-related standard operating procedures and processes.
Ensure compliance with Good Clinical Practice and global regulatory requirements.
Support inspection readiness and regulatory submissions related to clinical supply.
Develop and manage clinical supply budgets, forecasts, and spend tracking.
Provide leadership with regular updates on supply status, risks, and planning assumptions.
Lead, mentor, and develop a small clinical supply team and build scalable processes to support company growth.

Desired Qualifications

Oncology therapeutic-area experience is strongly preferred.
Experience supporting the transition from early-stage to late-stage clinical development.
Experience building or scaling clinical supply chain functions in an emerging biotech environment.

Salary Range: 257000 to 275000 (Currency: USD) (Pay period: per-year-salary)

Janux Therapeutics is seeking a Senior Director, Clinical Supply Chain will lead and execute Janux’s clinical supply strategy across Phase 1–3 programs, with a focus on enabling progression into late-stage development. This is a hands-on leadership role responsible for ensuring uninterrupted global supply of investigational medicinal product (IMP) while building scalable processes to support growing clinical program complexity.

This role partners closely with Clinical Operations, CMC, Quality, and Regulatory to align supply planning, manufacturing, and trial execution. The ideal candidate brings deep experience in biologics and global clinical trial supply, including hands-on support of late-stage clinical programs in a fast-paced biopharma environment.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

Lead and develop clinical supply strategies across Phase 1–3 programs

Ensure uninterrupted supply of IMP across global, multi-region clinical trials

Lead the team in end-to-end clinical supply operations, including packaging, labeling, distribution, returns, reconciliation and destruction.

Provide strategy and support in global logistics, including import/export activities and depot strategy, ensuring compliance with country-specific labeling and regulatory requirements

Provide strategic leadership, cross-functional alignment, and operational oversight to ensure the successful execution of key activities across Clinical Operations, Quality, Regulatory, and CMC functions.

Contribute to and review clinical trial documentation, including clinical protocols, pharmacy manuals, batch records, drug labels, and shipping documentation. Provide oversight of IRT strategy, setup, and execution

Partner closely with CMC to align manufacturing schedules with clinical supply needs and scale-up activitiesOversee comparator sourcing and supply strategies as needed

Select, manage, and oversee external vendors (CDMOs, depots, packaging and logistics providers), including RFPs, SOWs, and performance management

Partner with QA on vendor qualification, audits, compliance activities, and the development and maintenance of supply chain-related SOPs and processes.

Ensure compliance with GcPs, and global regulatory requirements

Support inspection readiness and regulatory submissions related to clinical supply

Develop and manage clinical supply budgets, forecasts, and spend tracking

Provide regular updates to leadership on supply status, risks, and planning assumptions

Lead, mentor, and develop a small clinical supply team and build scalable processes to support company growth

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

Bachelor’s degree in life sciences, supply chain, or related field

12+ years of experience in biotech/pharma supply chain with 4+ years of people management experience within a clinical supply chain organization.

Strong experience supporting Phase 2 and Phase 3 clinical trials

Proven experience supporting global clinical trials (including EU, APAC, Canada), including multi-region labeling and distribution requirements

Biologics experience required; oncology therapeutic area background strongly preferred

Demonstrated ability to operate in a hands-on role within a small to mid-size biotech environment

Strong expertise in clinical supply planning, forecasting, and inventory management

Experience managing external vendors, including CDMOs, depots, and logistics providers

Strong working knowledge of IRT systems and clinical supply infrastructure

Solid understanding of GcP guidelines, 21 CFR and Annex 13 requirements

Oncology experience strongly preferred

Experience supporting transition from early-stage to late-stage clinical development

Experience building or scaling clinical supply chain functions in an emerging biotech environment

Strong leadership and people management skills, with the ability to mentor and develop team members

Excellent cross-functional communication and stakeholder management skills

Ability to operate effectively in a fast-paced, evolving environment and navigate ambiguity

Strong problem-solving skills with a focus on practical execution

Job Type: Full-time

Benefits:

·Annual bonus program

·Incentive stock option plan

·401k plan with flat non-elective employer contribution

·Comprehensive medical insurance with 90-100% employer-paid premiums

·Dental and vision insurance

·HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)

·Unlimited PTO

·Generous holiday schedule; includes summer and winter company shutdown

·Relocation assistance

Schedule:

·Monday to Friday

Work authorization:

·United States (Required)

Additional Compensation:

·Annual targeted bonus %

Work Location:

· Hybrid preferred in San Diego office. Remote permitted upon approval, with ability to travel up to 25% for meetings or site visits as required.

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.

About the Company

Janux Therapeutics

Clinical-stage biotech developing tumor-activated immunotherapies

Janux Therapeutics develops cancer immunotherapies that activate the immune system inside tumors to attack cancer while sparing healthy tissue. Its products are tumor-activated and use a proprietary platform masking technology to reduce toxic side effects and improve efficacy compared with traditional T cell engagers. The company advances drug candidates through clinical trials, aiming for regulatory approval and eventual commercialization, with revenue expected from partnerships, licensing, and the sale of approved therapies. Its lead program JANX007 is being evaluated in a Phase 1 trial (ENGAGER PSMA 01) for metastatic prostate cancer to assess safety and preliminary effectiveness.

Company size: 51-200
Company stage: IPO
Headquarters: San Diego, CA
Founded: 2017

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